Thymosin β4 sustained release from poly(lactide-co-glycolide) microspheres: Synthesis and implications for treatment of myocardial ischemia

Jeffrey E. Thatcher, Tré Welch, Robert C. Eberhart, Zoltan A. Schelly, J. Michael Dimaio

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

A sustained release formulation for the therapeutic peptide thymosin β4 (Tβ4) that can be localized to the heart and reduce the concentration and frequency of dose is being explored as a means to improve its delivery in humans. This review contains concepts involved in the delivery of peptides to the heart and the synthesis of polymer microspheres for the sustained release of peptides, including Tβ4. Initial results of poly(lactic-co-glycolic acid) microspheres synthesized with specific tolerances for intramyocardial injection that demonstrate the encapsulation and release of Tβ4 from double-emulsion microspheres are also presented.

Original languageEnglish (US)
Pages (from-to)112-119
Number of pages8
JournalAnnals of the New York Academy of Sciences
Volume1270
Issue number1
DOIs
StatePublished - Oct 2012

Keywords

  • Controlled
  • Heart
  • Microsphere
  • Release
  • Sustained
  • Thymosin β4

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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