Thyroid and parathyroid (including thyroglossal disorders)

Jaimie D. Nathan, Michael A. Skinner

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Since the first thyroidectomy was reportedly performed by the Moorish surgeon Albucasis in AD 330, the surgical treatment of thyroid and parathyroid disorders has been approached with trepidation. Even with modern technical advances, many regard pathology in this anatomic location only operable by those with significant experience. This notion is especially true in children. The technical difficulties are more pronounced in younger individuals, and these children must survive a lifetime with the end result of their surgeon's work. In this chapter, the long-term outcome of surgical diseases of the thyroid and parathyroid glands, including thyroglossal disorders, in children is discussed. Graves' disease, the most common of these disorders, is the first entity considered. Malignancies of the thyroid gland are then considered with a discussion of papillary and follicular carcinoma, followed by a review of medullary carcinoma of the thyroid. Next, childhood disorders of the parathyroid glands are discussed, with emphasis on hyperparathyroidism. Finally, we consider the management and long term outcome of thyroglossal disorders, including cysts and sinuses. Toxic diffuse goiter or Graves' disease is the most common cause of hyperthyroidism in children. It is more common in girls than boys, with a ratio of approximately 4:1 to 5:1, and the incidence increases throughout childhood with a peak in the adolescent years. Graves' disease is an autoimmune process mediated by circulating autoantibodies to the thyroid stimulating hormone (TSH) receptor present on the follicular cells of the thyroid gland.

Original languageEnglish (US)
Title of host publicationPediatric Surgery and Urology
Subtitle of host publicationLong-Term Outcomes, Second Edition
PublisherCambridge University Press
Pages90-103
Number of pages14
ISBN (Electronic)9780511545757
ISBN (Print)0521839025, 9780521839020
DOIs
StatePublished - Jan 1 2006

ASJC Scopus subject areas

  • Medicine(all)

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    Nathan, J. D., & Skinner, M. A. (2006). Thyroid and parathyroid (including thyroglossal disorders). In Pediatric Surgery and Urology: Long-Term Outcomes, Second Edition (pp. 90-103). Cambridge University Press. https://doi.org/10.1017/CBO9780511545757.009