Thyrotropin-secreting adenoma in a patient with primary hypothyroidism

Research output: Contribution to journalArticle

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Abstract

Objective: To describe a patient who developed a thyrotropin (TSH)-secreting adenoma in the setting of primary hypothyroidism. Methods: We report the clinical, laboratory, and radiologic findings of a patient with a history of primary hypothyroidism who presented with headache, a bitemporal visual field deficit, and elevated TSH despite long-term levothyroxine therapy. We discuss the diagnostic challenges of this case and review the relevant literature.Results: A 54 year old woman with a history of primary hypothyroidism presented with a 3-year history of headache and a week of worsening vision. Imaging revealed a heterogeneous sellar mass elevating the optic chiasm. Her serum TSH was 46.5 mIU/L and free thyroxine concentration was 0.1 ng/dL. The differential diagnosis included pituitary hyperplasia and a TSH-secreting adenoma in a patient with primary hypothyroidism. The pathologic characteristics of the tumor were consistent with the latter. Conclusion: In a patient with an elevated TSH concentration and a previous diagnosis of hypothyroidism, it is important to consider other entities besides medication noncompliance. TSH-secreting adenomas can also cause elevated levels of TSH.

Original languageEnglish (US)
JournalEndocrine Practice
Volume17
Issue number6
DOIs
StatePublished - Nov 1 2011

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Thyrotropin
Hypothyroidism
Adenoma
Thyroxine
Headache
Optic Chiasm
Medication Adherence
Visual Fields
Hyperplasia
Differential Diagnosis
Serum
Neoplasms

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Thyrotropin-secreting adenoma in a patient with primary hypothyroidism. / Myers, Alyson; Hatanpaa, Kimmo; Madden, Christopher; Lingvay, Ildiko.

In: Endocrine Practice, Vol. 17, No. 6, 01.11.2011.

Research output: Contribution to journalArticle

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