Time course and temperature dependence of synaptic vesicle endocytosis

Natali L. Chanaday, Ege T Kavalali

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

In presynaptic nerve terminals, synaptic vesicles are recycled locally via an evolutionarily conserved process that ensures maintenance of neurotransmission as well as structural integrity of synapses. Temperature is a key environmental factor that impacts critical steps involved in fusion, endocytosis and transport in different vesicle trafficking pathways. In neurons, temperature changes have been shown to impact synaptic vesicle recycling and synaptic efficacy. But contrary to non-neuronal systems, the temperature dependence of the steps involved in fusion, endocytosis and recycling of synaptic vesicles in presynaptic terminals is not completely understood, and the existing data remain highly debated. In this Review, we discuss the implications of biophysical, biochemical and functional findings on temperature dependence of membrane retrieval in multiple systems. We propose that systematic investigation of the temperature dependence of the presynaptic vesicle trafficking process can provide novel insight into poorly understood mechanisms that govern synaptic vesicle trafficking under diverse physiological conditions.

Original languageEnglish (US)
Pages (from-to)3606-3614
Number of pages9
JournalFEBS Letters
Volume592
Issue number21
DOIs
StatePublished - Nov 1 2018

Fingerprint

Synaptic Vesicles
Endocytosis
Temperature
Presynaptic Terminals
Recycling
Fusion reactions
Structural integrity
Synaptic Transmission
Synapses
Neurons
Maintenance
Membranes

Keywords

  • endocytosis
  • neurotransmitter release
  • synaptic vesicle
  • temperature-dependence
  • vesicle fusion
  • vesicle retrieval

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Time course and temperature dependence of synaptic vesicle endocytosis. / Chanaday, Natali L.; Kavalali, Ege T.

In: FEBS Letters, Vol. 592, No. 21, 01.11.2018, p. 3606-3614.

Research output: Contribution to journalReview article

Chanaday, Natali L. ; Kavalali, Ege T. / Time course and temperature dependence of synaptic vesicle endocytosis. In: FEBS Letters. 2018 ; Vol. 592, No. 21. pp. 3606-3614.
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