Time for united action on depression: a Lancet–World Psychiatric Association Commission

Helen Herrman; Vikram Patel; Christian Kieling; Michael Berk; Claudia Buchweitz; Pim Cuijpers; Toshiaki A. Furukawa; Ronald C. Kessler; Brandon A. Kohrt; Mario Maj; Patrick McGorry; Charles F. Reynolds; Myrna M. Weissman; Dixon Chibanda; Christopher Dowrick; Louise M. Howard; Christina W. Hoven; Martin Knapp; Helen S. Mayberg; Brenda W.J.H. Penninx; Shuiyuan Xiao; Madhukar Trivedi; Rudolf Uher; Lakshmi Vijayakumar; Miranda Wolpert

doi:10.1016/S0140-6736(21)02141-3

Time for united action on depression: a Lancet–World Psychiatric Association Commission

Helen Herrman, Vikram Patel, Christian Kieling, Michael Berk, Claudia Buchweitz, Pim Cuijpers, Toshiaki A. Furukawa, Ronald C. Kessler, Brandon A. Kohrt, Mario Maj, Patrick McGorry, Charles F. Reynolds, Myrna M. Weissman, Dixon Chibanda, Christopher Dowrick, Louise M. Howard, Christina W. Hoven, Martin Knapp, Helen S. Mayberg, Brenda W.J.H. PenninxShuiyuan Xiao, Madhukar Trivedi, Rudolf Uher, Lakshmi Vijayakumar, Miranda Wolpert

Research output: Contribution to journal › Review article › peer-review

282 Scopus citations

Original language	English (US)
Pages (from-to)	957-1022
Number of pages	66
Journal	The Lancet
Volume	399
Issue number	10328
DOIs	https://doi.org/10.1016/S0140-6736(21)02141-3
State	Published - Mar 5 2022

ASJC Scopus subject areas

General Medicine

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10.1016/S0140-6736(21)02141-3

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Herrman, H., Patel, V., Kieling, C., Berk, M., Buchweitz, C., Cuijpers, P., Furukawa, T. A., Kessler, R. C., Kohrt, B. A., Maj, M., McGorry, P., Reynolds, C. F., Weissman, M. M., Chibanda, D., Dowrick, C., Howard, L. M., Hoven, C. W., Knapp, M., Mayberg, H. S., ... Wolpert, M. (2022). Time for united action on depression: a Lancet–World Psychiatric Association Commission. The Lancet, 399(10328), 957-1022. https://doi.org/10.1016/S0140-6736(21)02141-3

Herrman, H, Patel, V, Kieling, C, Berk, M, Buchweitz, C, Cuijpers, P, Furukawa, TA, Kessler, RC, Kohrt, BA, Maj, M, McGorry, P, Reynolds, CF, Weissman, MM, Chibanda, D, Dowrick, C, Howard, LM, Hoven, CW, Knapp, M, Mayberg, HS, Penninx, BWJH, Xiao, S, Trivedi, M, Uher, R, Vijayakumar, L & Wolpert, M 2022, 'Time for united action on depression: a Lancet–World Psychiatric Association Commission', The Lancet, vol. 399, no. 10328, pp. 957-1022. https://doi.org/10.1016/S0140-6736(21)02141-3

@article{7cd50f1c79fa402b810d06cbfa6d2649,

title = "Time for united action on depression: a Lancet–World Psychiatric Association Commission",

author = "Helen Herrman and Vikram Patel and Christian Kieling and Michael Berk and Claudia Buchweitz and Pim Cuijpers and Furukawa, {Toshiaki A.} and Kessler, {Ronald C.} and Kohrt, {Brandon A.} and Mario Maj and Patrick McGorry and Reynolds, {Charles F.} and Weissman, {Myrna M.} and Dixon Chibanda and Christopher Dowrick and Howard, {Louise M.} and Hoven, {Christina W.} and Martin Knapp and Mayberg, {Helen S.} and Penninx, {Brenda W.J.H.} and Shuiyuan Xiao and Madhukar Trivedi and Rudolf Uher and Lakshmi Vijayakumar and Miranda Wolpert",

note = "Funding Information: We thank the World Psychiatric Association for endorsement and support. We gratefully acknowledge foundational funding from The University of Melbourne. Generous funding support was also provided by the American Foundation for Suicide Prevention. Commission meetings were hosted by the Harvard Medical School in Boston, MA, USA, and by the Wellcome Trust in London, UK. The Wellcome Trust provided additional in-kind support as well as travel support for participants from low-income and middle-income countries. The Wellcome Trust and UNICEF worked together to support the participation of young people with lived experience as consultants in preparing the Commission, including crafting the recommendations. We thank Kate Martin (Wellcome Trust) and Marcy Levy (UNICEF) for their collegial work and advice, and Grace Gatera and Josiah Tavita Tualamali'I for their contribution. Sarah Kline, Charlene Sunkel and the Global Mental Health Peer Network, and Michaela Amering and the World Psychiatric Association Service User and Carer Advisory Group provided valuable advice and support in convening consultations on the report's recommendations. We thank United for Mental Health, especially Sarah Kline and Melanie Archer, for advance assistance with preparing for dissemination of the Commission, and The American Psychological Association for advice and invaluable assistance with dissemination of the Commission. We thank Prof Ellen Gay Detlefsen for providing a list of reliable websites on depression for the community, Ioana A Cristea for assistance with table 2, and Nancy A Sampson, Irving Hwang, and Wai Tat Chiu for support with figures generated with data from the WHO World Mental Health Survey Consortium. We also thank all the individuals from around the world who kindly provided testimonials. Funding Information: HH reports her role as President of the World Psychiatric Association during the period of preparing and submitting the Commission for publication, and support from an Australian National Health and Medical Research Council (NHMRC) Practitioner Fellowship. VP reports being a co-founder of Librum, a mental health consulting firm, and has consulted with Johnson & Johnson, with no fees received related to the submitted work. His research on depression is supported by the National Institute of Mental Health (NIMH) and the Wellcome Trust. CK is a researcher from Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico, Brazil, and a UK Academy of Medical Sciences Newton Advanced Fellow. MB reports grants from the NHMRC as Senior Principal Research Fellow, during the conduct of the study; personal fees from Servier, Lundbeck, Livanova, Grunbiotics, Otsuka, RANZCP, ANZJP, and Medisquire India, outside of the submitted work; and three issued patents (Modulation of Physiological processes and agents useful for same, Modulation of diseases of the central nervous system and related disorders, and Xanthone-rich plant extracts or compounds therefrom for modulating diseases of the central nervous system and related disorders issued). CB reports travel support from the Wellcome Trust and personal fees from the University of Melbourne and the World Psychiatric Association, during the conduct of the study. PC reports support for unrelated grants from the European Commission and ZonMw, and receives royalties for books and for occasional workshops and invited addresses. TAF reports grants and personal fees from Mitsubishi-Tanabe and Shionogi, and personal fees from Sony, outside of the submitted work. TAF also has a patent 2020-548587 concerning smartphone cognitive behavioural therapy applications pending, and intellectual properties for Kokoro-application licensed to Tanabe-Mitsubishi. RCK was a consultant for Datastat, Holmusk, RallyPoint Networks, and Sage Pharmaceuticals. He has stock options in Cerebral, Mirah, PYM, and Roga Sciences. CFR reports consultant fees from the Depression and Bipolar Support Alliance, Weill Cornell School of Medicine, UpToDate, The University of Maryland School of Public Health, Psychopharmacology Institute, and Merck; and an honorarium from the American Association for Geriatric Psychiatry, outside of the submitted work; and royalties from the University of Pittsburgh and Oxford University Press. Since 2018, MMW has received research funding from NIMH, Brain and Behavior Foundation, Templeton Foundation, and the Sackler Foundation, and has received book royalties from Perseus Press, Oxford University Press, and APA Publishing and royalties on the social adjustment scale from Multihealth Systems. DC is funded by the African Academy of Sciences and is a founder of Friendship Bench, which is supported by Boehringer Ingelheim, Draper Richards Kaplan Foundation, Mulago Foundation, Africa Visionary Fund, David Weekley Foundation, Grand Challenges Africa, Grand Challenges Canada, Schooner Foundation and Zoom Cares. CD reports grants from National Institute for Health and Social Care (England), personal fees from World Organisation of Family Doctors, personal fees from iheed—Accredited Medical Education Online (Ireland), outside of the submitted work; and as Chair of the Working Party for Mental Health of the World Organisation for Family Doctors, CD advocates for the central role of family doctors in the assessment and management of depression in primary care settings. LMH reports funding from the South London and Maudsley NHS Foundation Trust/King's College London Biomedical Research Centre; the UKRI Collaborative Mental Health Network plus: Violence, Abuse and Mental Health: Opportunities for change (ES/S004424/1); National Institute for Health Research (NIHR) HS&DR ESMI II: The Effectiveness and cost effectiveness of community perinatal Mental health services (17/49/38); and salary support from the South London NIHR Applied Research Collaboration. CWH reports funding from NIMH, National Institute of Drug Abuse, National Heart, Lung, and Blood Institute, Fogarty International Center, and Centers for Disease Control and Prevention–National Institute for Occupational Safety and Health. HSM reports personal fees from Abbott Laboratories, outside of the submitted work; and a patent US 2005/0033379A1 licensed to Abbott Laboratories. BWJHP reports grants from Jansen Research and Boehringer Ingelheim, outside of the submitted work. MT reports personal fees from Acadia Pharmaceuticals, Allergan, Alto Neuroscience, Axsome Therapeutics, Engage Health Media, GreenLight VitalSign6, Janssen, Merck Sharp & Dohme, Myriad Neuroscience, Navitor Pharmaceutical, Otsuka, Perception Neuroscience, SAGE Therapeutics, Signant Health, Academy Health, Akili Interactive, Health Research Associates, Jazz Pharmaceutical, Lundbeck Research USA, Perception Neuroscience Holdings, and Pharmerit International, outside of the submitted work. All other authors declare no competing interests. Funding Information: We thank the World Psychiatric Association for endorsement and support. We gratefully acknowledge foundational funding from The University of Melbourne. Generous funding support was also provided by the American Foundation for Suicide Prevention. Commission meetings were hosted by the Harvard Medical School in Boston, MA, USA, and by the Wellcome Trust in London, UK. The Wellcome Trust provided additional in-kind support as well as travel support for participants from low-income and middle-income countries. The Wellcome Trust and UNICEF worked together to support the participation of young people with lived experience as consultants in preparing the Commission, including crafting the recommendations. We thank Kate Martin (Wellcome Trust) and Marcy Levy (UNICEF) for their collegial work and advice, and Grace Gatera and Josiah Tavita Tualamali'I for their contribution. Sarah Kline, Charlene Sunkel and the Global Mental Health Peer Network, and Michaela Amering and the World Psychiatric Association Service User and Carer Advisory Group provided valuable advice and support in convening consultations on the report's recommendations. We thank United for Mental Health, especially Sarah Kline and Melanie Archer, for advance assistance with preparing for dissemination of the Commission, and The American Psychological Association for advice and invaluable assistance with dissemination of the Commission. We thank Prof Ellen Gay Detlefsen for providing a list of reliable websites on depression for the community, Ioana A Cristea for assistance with table 2 , and Nancy A Sampson, Irving Hwang, and Wai Tat Chiu for support with figures generated with data from the WHO World Mental Health Survey Consortium. We also thank all the individuals from around the world who kindly provided testimonials.",

year = "2022",

month = mar,

day = "5",

doi = "10.1016/S0140-6736(21)02141-3",

language = "English (US)",

volume = "399",

pages = "957--1022",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier Limited",

number = "10328",

}

TY - JOUR

T1 - Time for united action on depression

T2 - a Lancet–World Psychiatric Association Commission

AU - Herrman, Helen

AU - Patel, Vikram

AU - Kieling, Christian

AU - Berk, Michael

AU - Buchweitz, Claudia

AU - Cuijpers, Pim

AU - Furukawa, Toshiaki A.

AU - Kessler, Ronald C.

AU - Kohrt, Brandon A.

AU - Maj, Mario

AU - McGorry, Patrick

AU - Reynolds, Charles F.

AU - Weissman, Myrna M.

AU - Chibanda, Dixon

AU - Dowrick, Christopher

AU - Howard, Louise M.

AU - Hoven, Christina W.

AU - Knapp, Martin

AU - Mayberg, Helen S.

AU - Penninx, Brenda W.J.H.

AU - Xiao, Shuiyuan

AU - Trivedi, Madhukar

AU - Uher, Rudolf

AU - Vijayakumar, Lakshmi

AU - Wolpert, Miranda

N1 - Funding Information: We thank the World Psychiatric Association for endorsement and support. We gratefully acknowledge foundational funding from The University of Melbourne. Generous funding support was also provided by the American Foundation for Suicide Prevention. Commission meetings were hosted by the Harvard Medical School in Boston, MA, USA, and by the Wellcome Trust in London, UK. The Wellcome Trust provided additional in-kind support as well as travel support for participants from low-income and middle-income countries. The Wellcome Trust and UNICEF worked together to support the participation of young people with lived experience as consultants in preparing the Commission, including crafting the recommendations. We thank Kate Martin (Wellcome Trust) and Marcy Levy (UNICEF) for their collegial work and advice, and Grace Gatera and Josiah Tavita Tualamali'I for their contribution. Sarah Kline, Charlene Sunkel and the Global Mental Health Peer Network, and Michaela Amering and the World Psychiatric Association Service User and Carer Advisory Group provided valuable advice and support in convening consultations on the report's recommendations. We thank United for Mental Health, especially Sarah Kline and Melanie Archer, for advance assistance with preparing for dissemination of the Commission, and The American Psychological Association for advice and invaluable assistance with dissemination of the Commission. We thank Prof Ellen Gay Detlefsen for providing a list of reliable websites on depression for the community, Ioana A Cristea for assistance with table 2, and Nancy A Sampson, Irving Hwang, and Wai Tat Chiu for support with figures generated with data from the WHO World Mental Health Survey Consortium. We also thank all the individuals from around the world who kindly provided testimonials. Funding Information: HH reports her role as President of the World Psychiatric Association during the period of preparing and submitting the Commission for publication, and support from an Australian National Health and Medical Research Council (NHMRC) Practitioner Fellowship. VP reports being a co-founder of Librum, a mental health consulting firm, and has consulted with Johnson & Johnson, with no fees received related to the submitted work. His research on depression is supported by the National Institute of Mental Health (NIMH) and the Wellcome Trust. CK is a researcher from Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil, and a UK Academy of Medical Sciences Newton Advanced Fellow. MB reports grants from the NHMRC as Senior Principal Research Fellow, during the conduct of the study; personal fees from Servier, Lundbeck, Livanova, Grunbiotics, Otsuka, RANZCP, ANZJP, and Medisquire India, outside of the submitted work; and three issued patents (Modulation of Physiological processes and agents useful for same, Modulation of diseases of the central nervous system and related disorders, and Xanthone-rich plant extracts or compounds therefrom for modulating diseases of the central nervous system and related disorders issued). CB reports travel support from the Wellcome Trust and personal fees from the University of Melbourne and the World Psychiatric Association, during the conduct of the study. PC reports support for unrelated grants from the European Commission and ZonMw, and receives royalties for books and for occasional workshops and invited addresses. TAF reports grants and personal fees from Mitsubishi-Tanabe and Shionogi, and personal fees from Sony, outside of the submitted work. TAF also has a patent 2020-548587 concerning smartphone cognitive behavioural therapy applications pending, and intellectual properties for Kokoro-application licensed to Tanabe-Mitsubishi. RCK was a consultant for Datastat, Holmusk, RallyPoint Networks, and Sage Pharmaceuticals. He has stock options in Cerebral, Mirah, PYM, and Roga Sciences. CFR reports consultant fees from the Depression and Bipolar Support Alliance, Weill Cornell School of Medicine, UpToDate, The University of Maryland School of Public Health, Psychopharmacology Institute, and Merck; and an honorarium from the American Association for Geriatric Psychiatry, outside of the submitted work; and royalties from the University of Pittsburgh and Oxford University Press. Since 2018, MMW has received research funding from NIMH, Brain and Behavior Foundation, Templeton Foundation, and the Sackler Foundation, and has received book royalties from Perseus Press, Oxford University Press, and APA Publishing and royalties on the social adjustment scale from Multihealth Systems. DC is funded by the African Academy of Sciences and is a founder of Friendship Bench, which is supported by Boehringer Ingelheim, Draper Richards Kaplan Foundation, Mulago Foundation, Africa Visionary Fund, David Weekley Foundation, Grand Challenges Africa, Grand Challenges Canada, Schooner Foundation and Zoom Cares. CD reports grants from National Institute for Health and Social Care (England), personal fees from World Organisation of Family Doctors, personal fees from iheed—Accredited Medical Education Online (Ireland), outside of the submitted work; and as Chair of the Working Party for Mental Health of the World Organisation for Family Doctors, CD advocates for the central role of family doctors in the assessment and management of depression in primary care settings. LMH reports funding from the South London and Maudsley NHS Foundation Trust/King's College London Biomedical Research Centre; the UKRI Collaborative Mental Health Network plus: Violence, Abuse and Mental Health: Opportunities for change (ES/S004424/1); National Institute for Health Research (NIHR) HS&DR ESMI II: The Effectiveness and cost effectiveness of community perinatal Mental health services (17/49/38); and salary support from the South London NIHR Applied Research Collaboration. CWH reports funding from NIMH, National Institute of Drug Abuse, National Heart, Lung, and Blood Institute, Fogarty International Center, and Centers for Disease Control and Prevention–National Institute for Occupational Safety and Health. HSM reports personal fees from Abbott Laboratories, outside of the submitted work; and a patent US 2005/0033379A1 licensed to Abbott Laboratories. BWJHP reports grants from Jansen Research and Boehringer Ingelheim, outside of the submitted work. MT reports personal fees from Acadia Pharmaceuticals, Allergan, Alto Neuroscience, Axsome Therapeutics, Engage Health Media, GreenLight VitalSign6, Janssen, Merck Sharp & Dohme, Myriad Neuroscience, Navitor Pharmaceutical, Otsuka, Perception Neuroscience, SAGE Therapeutics, Signant Health, Academy Health, Akili Interactive, Health Research Associates, Jazz Pharmaceutical, Lundbeck Research USA, Perception Neuroscience Holdings, and Pharmerit International, outside of the submitted work. All other authors declare no competing interests. Funding Information: We thank the World Psychiatric Association for endorsement and support. We gratefully acknowledge foundational funding from The University of Melbourne. Generous funding support was also provided by the American Foundation for Suicide Prevention. Commission meetings were hosted by the Harvard Medical School in Boston, MA, USA, and by the Wellcome Trust in London, UK. The Wellcome Trust provided additional in-kind support as well as travel support for participants from low-income and middle-income countries. The Wellcome Trust and UNICEF worked together to support the participation of young people with lived experience as consultants in preparing the Commission, including crafting the recommendations. We thank Kate Martin (Wellcome Trust) and Marcy Levy (UNICEF) for their collegial work and advice, and Grace Gatera and Josiah Tavita Tualamali'I for their contribution. Sarah Kline, Charlene Sunkel and the Global Mental Health Peer Network, and Michaela Amering and the World Psychiatric Association Service User and Carer Advisory Group provided valuable advice and support in convening consultations on the report's recommendations. We thank United for Mental Health, especially Sarah Kline and Melanie Archer, for advance assistance with preparing for dissemination of the Commission, and The American Psychological Association for advice and invaluable assistance with dissemination of the Commission. We thank Prof Ellen Gay Detlefsen for providing a list of reliable websites on depression for the community, Ioana A Cristea for assistance with table 2 , and Nancy A Sampson, Irving Hwang, and Wai Tat Chiu for support with figures generated with data from the WHO World Mental Health Survey Consortium. We also thank all the individuals from around the world who kindly provided testimonials.

PY - 2022/3/5

Y1 - 2022/3/5

UR - http://www.scopus.com/inward/record.url?scp=85125525353&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85125525353&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(21)02141-3

DO - 10.1016/S0140-6736(21)02141-3

M3 - Review article

C2 - 35180424

AN - SCOPUS:85125525353

SN - 0140-6736

VL - 399

SP - 957

EP - 1022

JO - The Lancet

JF - The Lancet

IS - 10328

ER -

Time for united action on depression: a Lancet–World Psychiatric Association Commission

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