TY - JOUR
T1 - Time-kill studies of antibiotic combinations against penicillin-resistant and -susceptible streptococcus pneumoniae
AU - Friedland, Ian R.
AU - Paris, Maria
AU - Shelton, Sharon
AU - Mccracken, George H.
PY - 1994/8
Y1 - 1994/8
N2 - Time-kill studies were conducted to evaluate antibiotic combinations against four strains of Streptococcus pneumoniae for which the MICs of penicillin were 0.03, 0.25, 1 and 4 mg/L, respectively. After 8 h of antibiotic exposure the combination of ceftriaxone and vancomycin showed enhanced activity against all four strains. Penicillin plus vancomycin and ceftriaxone plus gentamicin showed enhanced activity against the three penicillin-resistant strains. Combinations of vancomycin and rifampicin were indifferent. These results are similar to those found previously in the rabbit meningitis model suggesting that time-kill studies over 8 h may be useful in predicting in-vivo antibiotic interactions in resistant pneumococcal infections.
AB - Time-kill studies were conducted to evaluate antibiotic combinations against four strains of Streptococcus pneumoniae for which the MICs of penicillin were 0.03, 0.25, 1 and 4 mg/L, respectively. After 8 h of antibiotic exposure the combination of ceftriaxone and vancomycin showed enhanced activity against all four strains. Penicillin plus vancomycin and ceftriaxone plus gentamicin showed enhanced activity against the three penicillin-resistant strains. Combinations of vancomycin and rifampicin were indifferent. These results are similar to those found previously in the rabbit meningitis model suggesting that time-kill studies over 8 h may be useful in predicting in-vivo antibiotic interactions in resistant pneumococcal infections.
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U2 - 10.1093/jac/34.2.231
DO - 10.1093/jac/34.2.231
M3 - Article
C2 - 7814283
AN - SCOPUS:0028673572
SN - 0305-7453
VL - 34
SP - 231
EP - 237
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
IS - 2
ER -