Time to move the fat

Benjamin P. Weaver, Aileen K. Sewell, Min Han

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

In this issue of Genes & Development, Dowen and colleagues (pp. 1515-1528) elegantly unify two previously unconnected aspects of physiology. The investigators provide significant genetic evidence to support a critical link between developmental timing decisions and the regulation of lipid mobilization at the transition to adulthood in Caenorhabditis elegans. This novel connection involves cross-tissue signaling fromthe hypodermis (epidermis) to the intestine to promote reproductive success in the germline.

Original languageEnglish (US)
Pages (from-to)1481-1482
Number of pages2
JournalGenes and Development
Volume30
Issue number13
DOIs
StatePublished - Jul 1 2016
Externally publishedYes

Keywords

  • Fat metabolism
  • Insulin
  • MicroRNAs
  • MTORC2
  • Pqm-1
  • Vitellogenesis

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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