Time trends in cancer incidence in persons living with HIV/AIDS in the antiretroviral therapy era

1997–2012

Lesley S. Park, Janet P. Tate, Keith Sigel, David Rimland, Kristina Crothers, Cynthia Gibert, Maria C. Rodriguez-Barradas, Matthew Bidwell Goetz, Roger J. Bedimo, Sheldon T. Brown, Amy C. Justice, Robert Dubrow

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

OBJECTIVE:: Utilizing the Veterans Aging Cohort Study, the largest HIV cohort in North America, we conducted one of the few comprehensive comparisons of cancer incidence time trends in HIV-infected (HIV+) versus uninfected persons during the antiretroviral therapy (ART) era. DESIGN:: Prospective cohort study. METHODS:: We followed 44,787 HIV+ and 96,852 demographically-matched uninfected persons during 1997–2012. We calculated age-, sex-, and race/ethnicity-standardized incidence rates (IR) and incidence rate ratios (IRR, HIV+ versus uninfected) over four calendar periods with IR and IRR period trend p-values for cancer groupings and specific cancer types. RESULTS:: We observed 3,714 incident cancer diagnoses in HIV+ and 5,760 in uninfected persons. The HIV+ all cancer crude IR increased between 1997–2000 and 2009–2012 (p-trend?=?0.0019). However, after standardization, we observed highly significant HIV+ IR declines for all cancer (25% decline; p-trend

Original languageEnglish (US)
JournalAIDS
DOIs
StateAccepted/In press - Apr 8 2016

Fingerprint

Acquired Immunodeficiency Syndrome
HIV
Incidence
Neoplasms
Therapeutics
Cohort Studies
Veterans
North America
Prospective Studies

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Park, L. S., Tate, J. P., Sigel, K., Rimland, D., Crothers, K., Gibert, C., ... Dubrow, R. (Accepted/In press). Time trends in cancer incidence in persons living with HIV/AIDS in the antiretroviral therapy era: 1997–2012. AIDS. https://doi.org/10.1097/QAD.0000000000001112

Time trends in cancer incidence in persons living with HIV/AIDS in the antiretroviral therapy era : 1997–2012. / Park, Lesley S.; Tate, Janet P.; Sigel, Keith; Rimland, David; Crothers, Kristina; Gibert, Cynthia; Rodriguez-Barradas, Maria C.; Goetz, Matthew Bidwell; Bedimo, Roger J.; Brown, Sheldon T.; Justice, Amy C.; Dubrow, Robert.

In: AIDS, 08.04.2016.

Research output: Contribution to journalArticle

Park, LS, Tate, JP, Sigel, K, Rimland, D, Crothers, K, Gibert, C, Rodriguez-Barradas, MC, Goetz, MB, Bedimo, RJ, Brown, ST, Justice, AC & Dubrow, R 2016, 'Time trends in cancer incidence in persons living with HIV/AIDS in the antiretroviral therapy era: 1997–2012', AIDS. https://doi.org/10.1097/QAD.0000000000001112
Park, Lesley S. ; Tate, Janet P. ; Sigel, Keith ; Rimland, David ; Crothers, Kristina ; Gibert, Cynthia ; Rodriguez-Barradas, Maria C. ; Goetz, Matthew Bidwell ; Bedimo, Roger J. ; Brown, Sheldon T. ; Justice, Amy C. ; Dubrow, Robert. / Time trends in cancer incidence in persons living with HIV/AIDS in the antiretroviral therapy era : 1997–2012. In: AIDS. 2016.
@article{3d17c90aa37042aea438b1ada9e29734,
title = "Time trends in cancer incidence in persons living with HIV/AIDS in the antiretroviral therapy era: 1997–2012",
abstract = "OBJECTIVE:: Utilizing the Veterans Aging Cohort Study, the largest HIV cohort in North America, we conducted one of the few comprehensive comparisons of cancer incidence time trends in HIV-infected (HIV+) versus uninfected persons during the antiretroviral therapy (ART) era. DESIGN:: Prospective cohort study. METHODS:: We followed 44,787 HIV+ and 96,852 demographically-matched uninfected persons during 1997–2012. We calculated age-, sex-, and race/ethnicity-standardized incidence rates (IR) and incidence rate ratios (IRR, HIV+ versus uninfected) over four calendar periods with IR and IRR period trend p-values for cancer groupings and specific cancer types. RESULTS:: We observed 3,714 incident cancer diagnoses in HIV+ and 5,760 in uninfected persons. The HIV+ all cancer crude IR increased between 1997–2000 and 2009–2012 (p-trend?=?0.0019). However, after standardization, we observed highly significant HIV+ IR declines for all cancer (25{\%} decline; p-trend",
author = "Park, {Lesley S.} and Tate, {Janet P.} and Keith Sigel and David Rimland and Kristina Crothers and Cynthia Gibert and Rodriguez-Barradas, {Maria C.} and Goetz, {Matthew Bidwell} and Bedimo, {Roger J.} and Brown, {Sheldon T.} and Justice, {Amy C.} and Robert Dubrow",
year = "2016",
month = "4",
day = "8",
doi = "10.1097/QAD.0000000000001112",
language = "English (US)",
journal = "AIDS",
issn = "0269-9370",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Time trends in cancer incidence in persons living with HIV/AIDS in the antiretroviral therapy era

T2 - 1997–2012

AU - Park, Lesley S.

AU - Tate, Janet P.

AU - Sigel, Keith

AU - Rimland, David

AU - Crothers, Kristina

AU - Gibert, Cynthia

AU - Rodriguez-Barradas, Maria C.

AU - Goetz, Matthew Bidwell

AU - Bedimo, Roger J.

AU - Brown, Sheldon T.

AU - Justice, Amy C.

AU - Dubrow, Robert

PY - 2016/4/8

Y1 - 2016/4/8

N2 - OBJECTIVE:: Utilizing the Veterans Aging Cohort Study, the largest HIV cohort in North America, we conducted one of the few comprehensive comparisons of cancer incidence time trends in HIV-infected (HIV+) versus uninfected persons during the antiretroviral therapy (ART) era. DESIGN:: Prospective cohort study. METHODS:: We followed 44,787 HIV+ and 96,852 demographically-matched uninfected persons during 1997–2012. We calculated age-, sex-, and race/ethnicity-standardized incidence rates (IR) and incidence rate ratios (IRR, HIV+ versus uninfected) over four calendar periods with IR and IRR period trend p-values for cancer groupings and specific cancer types. RESULTS:: We observed 3,714 incident cancer diagnoses in HIV+ and 5,760 in uninfected persons. The HIV+ all cancer crude IR increased between 1997–2000 and 2009–2012 (p-trend?=?0.0019). However, after standardization, we observed highly significant HIV+ IR declines for all cancer (25% decline; p-trend

AB - OBJECTIVE:: Utilizing the Veterans Aging Cohort Study, the largest HIV cohort in North America, we conducted one of the few comprehensive comparisons of cancer incidence time trends in HIV-infected (HIV+) versus uninfected persons during the antiretroviral therapy (ART) era. DESIGN:: Prospective cohort study. METHODS:: We followed 44,787 HIV+ and 96,852 demographically-matched uninfected persons during 1997–2012. We calculated age-, sex-, and race/ethnicity-standardized incidence rates (IR) and incidence rate ratios (IRR, HIV+ versus uninfected) over four calendar periods with IR and IRR period trend p-values for cancer groupings and specific cancer types. RESULTS:: We observed 3,714 incident cancer diagnoses in HIV+ and 5,760 in uninfected persons. The HIV+ all cancer crude IR increased between 1997–2000 and 2009–2012 (p-trend?=?0.0019). However, after standardization, we observed highly significant HIV+ IR declines for all cancer (25% decline; p-trend

UR - http://www.scopus.com/inward/record.url?scp=84963682613&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84963682613&partnerID=8YFLogxK

U2 - 10.1097/QAD.0000000000001112

DO - 10.1097/QAD.0000000000001112

M3 - Article

JO - AIDS

JF - AIDS

SN - 0269-9370

ER -