Time trends in cancer incidence in persons living with HIV/AIDS in the antiretroviral therapy era: 1997–2012

Lesley S. Park, Janet P. Tate, Keith Sigel, David Rimland, Kristina Crothers, Cynthia Gibert, Maria C. Rodriguez-Barradas, Matthew Bidwell Goetz, Roger J. Bedimo, Sheldon T. Brown, Amy C. Justice, Robert Dubrow

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

OBJECTIVE:: Utilizing the Veterans Aging Cohort Study, the largest HIV cohort in North America, we conducted one of the few comprehensive comparisons of cancer incidence time trends in HIV-infected (HIV+) versus uninfected persons during the antiretroviral therapy (ART) era. DESIGN:: Prospective cohort study. METHODS:: We followed 44,787 HIV+ and 96,852 demographically-matched uninfected persons during 1997–2012. We calculated age-, sex-, and race/ethnicity-standardized incidence rates (IR) and incidence rate ratios (IRR, HIV+ versus uninfected) over four calendar periods with IR and IRR period trend p-values for cancer groupings and specific cancer types. RESULTS:: We observed 3,714 incident cancer diagnoses in HIV+ and 5,760 in uninfected persons. The HIV+ all cancer crude IR increased between 1997–2000 and 2009–2012 (p-trend?=?0.0019). However, after standardization, we observed highly significant HIV+ IR declines for all cancer (25% decline; p-trend

Original languageEnglish (US)
JournalAIDS
DOIs
Publication statusAccepted/In press - Apr 8 2016

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Park, L. S., Tate, J. P., Sigel, K., Rimland, D., Crothers, K., Gibert, C., ... Dubrow, R. (Accepted/In press). Time trends in cancer incidence in persons living with HIV/AIDS in the antiretroviral therapy era: 1997–2012. AIDS. https://doi.org/10.1097/QAD.0000000000001112