@article{738e9253dc4c410e8b9241a9b65d339c,
title = "Timing of postnatal steroids for bronchopulmonary dysplasia: association with pulmonary and neurodevelopmental outcomes",
abstract = "Objective: To determine the associations between age at first postnatal corticosteroids (PNS) exposure and risk for severe bronchopulmonary dysplasia (BPD) and neurodevelopmental impairment (NDI). Study design: Cohort study of 951 infants born <27 weeks gestational age at NICHD Neonatal Research Network sites who received PNS between 8 days of life (DOL) and 36 weeks{\textquoteright} postmenstrual age was used to produce adjusted odds ratios (aOR). Results: Compared with infants in the reference group (22–28 DOL-lowest rate), aOR for severe BPD was similar for children given PNS between DOL 8 and 49 but higher among infants treated at DOL 50–63 (aOR 1.77, 95% CI 1.03–3.06), and at DOL ≥64 (aOR 3.06, 95% CI 1.44–6.48). The aOR for NDI did not vary significantly by age of PNS exposure. Conclusion: For infants at high risk of BPD, initial PNS should be considered prior to 50 DOL for the lowest associated odds of severe BPD.",
author = "{for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network} and Harmon, {Heidi M.} and Jensen, {Erik A.} and Sylvia Tan and Chaudhary, {Aasma S.} and Slaughter, {Jonathan L.} and Bell, {Edward F.} and Wyckoff, {Myra H.} and Hensman, {Angelita M.} and Sokol, {Gregory M.} and DeMauro, {Sara B.} and Caplan, {Michael S.} and Laptook, {Abbott R.} and Martin Keszler and Vohr, {Betty R.} and Barbara Alksninis and Basso, {Kristin M.} and Robert Burke and Melinda Caskey and Katharine Johnson and Keszler, {Mary Lenore} and Knoll, {Andrea M.} and Leach, {Theresa M.} and Emilee Little and McGowan, {Elisabeth C.} and Elisa Vieira and Watson, {Victoria E.} and Suzy Ventura and Walsh, {Michele C.} and Hibbs, {Anna Maria} and Wilson-Costello, {Deanne E.} and Newman, {Nancy S.} and Payne, {Allison H.} and Siner, {Bonnie S.} and Monika Bhola and Gulgun Yalcinkaya and Truog, {William E.} and Pallotto, {Eugenia K.} and Kilbride, {Howard W.} and Cheri Gauldin and Anne Holmes and Kathy Johnson and Allison Scott and Kurt Schibler and Donovan, {Edward F.} and Cathy Grisby and Kate Bridges and Sanchez, {Pablo J.} and Brion, {Luc P.} and Heyne, {Roy J.} and Rosenfeld, {Charles R.}",
note = "Publisher Copyright: {\textcopyright} 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2020",
month = apr,
day = "1",
doi = "10.1038/s41372-020-0594-4",
language = "English (US)",
volume = "40",
pages = "616--627",
journal = "Journal of Perinatology",
issn = "0743-8346",
publisher = "Nature Publishing Group",
number = "4",
}