tint maps to mouse chromosome 6 and may interact with a notochordal enhancer of Brachyury

Jiang I. Wu, M. A. Centilli, Gabriela Vasquez, Susan Young, Jonathan Scolnick, Larissa A. Durfee, Jimmy L. Spearow, Staci D. Schwantz, Gabriela Rennebeck, Karen Artzt

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

At the proximal part of mouse chromosome 17 there are three well-defined genes affecting the axis of the embryo and consequently tail length: Brachyury, Brachyury the second, and the t-complex tail interaction (T1, T2, and tct). The existence of T1 and tct in fact defines the classical "t-complex" that occupies ∼40 cM of mouse chromosome 17. Their relationship to each other and various unlinked interacting genes has been enigmatic. The tint gene was the first of the latter to be identified. We report here its genetic mapping using a microsatellite scan together with outcrosses to Mus spretus and M. castaneous followed by a subsequent testcross to T, T1, and T2 mutants. Surprisingly, tint interacts with T2 but not with T1. The implications of our data suggest that T2 may be part of the T1 regulatory region through direct or indirect participation of tint.

Original languageEnglish (US)
Pages (from-to)1151-1161
Number of pages11
JournalGenetics
Volume177
Issue number2
DOIs
StatePublished - Oct 2007

Fingerprint

Chromosomes, Human, Pair 6
Chromosomes, Human, Pair 17
Tail
Genes
Nucleic Acid Regulatory Sequences
Microsatellite Repeats
Embryonic Structures
Brachyury protein

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Wu, J. I., Centilli, M. A., Vasquez, G., Young, S., Scolnick, J., Durfee, L. A., ... Artzt, K. (2007). tint maps to mouse chromosome 6 and may interact with a notochordal enhancer of Brachyury. Genetics, 177(2), 1151-1161. https://doi.org/10.1534/genetics.107.079715

tint maps to mouse chromosome 6 and may interact with a notochordal enhancer of Brachyury. / Wu, Jiang I.; Centilli, M. A.; Vasquez, Gabriela; Young, Susan; Scolnick, Jonathan; Durfee, Larissa A.; Spearow, Jimmy L.; Schwantz, Staci D.; Rennebeck, Gabriela; Artzt, Karen.

In: Genetics, Vol. 177, No. 2, 10.2007, p. 1151-1161.

Research output: Contribution to journalArticle

Wu, JI, Centilli, MA, Vasquez, G, Young, S, Scolnick, J, Durfee, LA, Spearow, JL, Schwantz, SD, Rennebeck, G & Artzt, K 2007, 'tint maps to mouse chromosome 6 and may interact with a notochordal enhancer of Brachyury', Genetics, vol. 177, no. 2, pp. 1151-1161. https://doi.org/10.1534/genetics.107.079715
Wu, Jiang I. ; Centilli, M. A. ; Vasquez, Gabriela ; Young, Susan ; Scolnick, Jonathan ; Durfee, Larissa A. ; Spearow, Jimmy L. ; Schwantz, Staci D. ; Rennebeck, Gabriela ; Artzt, Karen. / tint maps to mouse chromosome 6 and may interact with a notochordal enhancer of Brachyury. In: Genetics. 2007 ; Vol. 177, No. 2. pp. 1151-1161.
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AU - Scolnick, Jonathan

AU - Durfee, Larissa A.

AU - Spearow, Jimmy L.

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