Tipping the balance by manipulating post-translational modifications

Christopher A. Broberg, Kim Orth

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Bacteria use a variety of mechanisms during infection to ensure their survival including the delivery of virulence factors via a type III secretion system into the infected cell. The factors exhibit diverse activities that in many cases mimic eukaryotic mechanisms used by the host to defend against infection. Herein we describe a class of effectors that use post-translational modifications, some reversible and others irreversible, to manipulate host signaling systems to subvert the host response.

Original languageEnglish (US)
Pages (from-to)34-40
Number of pages7
JournalCurrent Opinion in Microbiology
Volume13
Issue number1
DOIs
StatePublished - Feb 2010

Fingerprint

Post Translational Protein Processing
Virulence Factors
Infection
Bacteria
Type III Secretion Systems

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology

Cite this

Tipping the balance by manipulating post-translational modifications. / Broberg, Christopher A.; Orth, Kim.

In: Current Opinion in Microbiology, Vol. 13, No. 1, 02.2010, p. 34-40.

Research output: Contribution to journalArticle

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