Abstract
Bacteria use a variety of mechanisms during infection to ensure their survival including the delivery of virulence factors via a type III secretion system into the infected cell. The factors exhibit diverse activities that in many cases mimic eukaryotic mechanisms used by the host to defend against infection. Herein we describe a class of effectors that use post-translational modifications, some reversible and others irreversible, to manipulate host signaling systems to subvert the host response.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 34-40 |
| Number of pages | 7 |
| Journal | Current Opinion in Microbiology |
| Volume | 13 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 2010 |
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ASJC Scopus subject areas
- Infectious Diseases
- Microbiology (medical)
- Microbiology
Cite this
Tipping the balance by manipulating post-translational modifications. / Broberg, Christopher A.; Orth, Kim.
In: Current Opinion in Microbiology, Vol. 13, No. 1, 02.2010, p. 34-40.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tipping the balance by manipulating post-translational modifications
AU - Broberg, Christopher A.
AU - Orth, Kim
PY - 2010/2
Y1 - 2010/2
N2 - Bacteria use a variety of mechanisms during infection to ensure their survival including the delivery of virulence factors via a type III secretion system into the infected cell. The factors exhibit diverse activities that in many cases mimic eukaryotic mechanisms used by the host to defend against infection. Herein we describe a class of effectors that use post-translational modifications, some reversible and others irreversible, to manipulate host signaling systems to subvert the host response.
AB - Bacteria use a variety of mechanisms during infection to ensure their survival including the delivery of virulence factors via a type III secretion system into the infected cell. The factors exhibit diverse activities that in many cases mimic eukaryotic mechanisms used by the host to defend against infection. Herein we describe a class of effectors that use post-translational modifications, some reversible and others irreversible, to manipulate host signaling systems to subvert the host response.
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UR - http://www.scopus.com/inward/citedby.url?scp=75249095752&partnerID=8YFLogxK
U2 - 10.1016/j.mib.2009.12.004
DO - 10.1016/j.mib.2009.12.004
M3 - Article
C2 - 20071215
AN - SCOPUS:75249095752
VL - 13
SP - 34
EP - 40
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
SN - 1369-5274
IS - 1
ER -