TY - JOUR
T1 - Tipping the balance by manipulating post-translational modifications
AU - Broberg, Christopher A.
AU - Orth, Kim
N1 - Funding Information:
We thank Melanie Yarbrough for critical reading and helpful discussions, and members of the K.O. laboratory for their kind support. K.O. and C.A.B. are supported by National Institutes of Health-AID Grant R01-AI056404 and Grant I-1561 from the Welch Research Foundation. C.A.B. is supported by NIGMS training grant 5T32GM008203 in cellular and molecular biology. K.O. is a Burroughs Wellcome Investigator in Pathogenesis of Infectious Disease and a W.W. Caruth, Jr. Biomedical Scholar.
PY - 2010/2
Y1 - 2010/2
N2 - Bacteria use a variety of mechanisms during infection to ensure their survival including the delivery of virulence factors via a type III secretion system into the infected cell. The factors exhibit diverse activities that in many cases mimic eukaryotic mechanisms used by the host to defend against infection. Herein we describe a class of effectors that use post-translational modifications, some reversible and others irreversible, to manipulate host signaling systems to subvert the host response.
AB - Bacteria use a variety of mechanisms during infection to ensure their survival including the delivery of virulence factors via a type III secretion system into the infected cell. The factors exhibit diverse activities that in many cases mimic eukaryotic mechanisms used by the host to defend against infection. Herein we describe a class of effectors that use post-translational modifications, some reversible and others irreversible, to manipulate host signaling systems to subvert the host response.
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U2 - 10.1016/j.mib.2009.12.004
DO - 10.1016/j.mib.2009.12.004
M3 - Review article
C2 - 20071215
AN - SCOPUS:75249095752
VL - 13
SP - 34
EP - 40
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
SN - 1369-5274
IS - 1
ER -