@article{f0131d80c6f04130ba6af85e47122d2f,
title = "Tissue oxygen saturation predicts response to breast cancer neoadjuvant chemotherapy within 10 days of treatment",
abstract = "Ideally, Neoadjuvant chemotherapy (NAC) assessment should predict pathologic complete response (pCR), a surrogate clinical endpoint for 5-year survival, as early as possible during typical 3-to 6-month breast cancer treatments. We introduce and demonstrate an approach for predicting pCR within 10 days of initiating NAC. The method uses a bedside diffuse optical spectroscopic imaging (DOSI) technology and logistic regression modeling. Tumor and normal tissue physiological properties were measured longitudinally throughout the course of NAC in 33 patients enrolled in the American College of Radiology Imaging Network multicenter breast cancer DOSI trial (ACRIN-6691). An image analysis scheme, employing z-score normalization to healthy tissue, produced models with robust predictions. Notably, logistic regression based on z-score normalization using only tissue oxygen saturation (StO2) measured within 10 days of the initial therapy dose was found to be a significant predictor of pCR (AUC = 0.92; 95% CI: 0.82 to 1). This observation suggests that patients who show rapid convergence of tumor tissue StO2 to surrounding tissue StO2 are more likely to achieve pCR. This early predictor of pCR occurs prior to reductions in tumor size and could enable dynamic feedback for optimization of chemotherapy strategies in breast cancer.",
keywords = "Biomedical Optics, Breast Cancer, Diffuse Optical Spectroscopy, Neoadjuvant Chemotherapy, Therapy Monitoring, Translational Imaging",
author = "Cochran, {Jeffrey M.} and Busch, {David R.} and Ana{\"i}s Leproux and Zheng Zhang and O'Sullivan, {Thomas D.} and Cerussi, {Albert E.} and Carpenter, {Philip M.} and Mehta, {Rita S.} and Darren Roblyer and Wei Yang and Paulsen, {Keith D.} and Brian Pogue and Shudong Jiang and Kaufman, {Peter A.} and Chung, {So Hyun} and Mitchell Schnall and Snyder, {Bradley S.} and Nola Hylton and Carp, {Stefan A.} and Isakoff, {Steven J.} and David Mankoff and Tromberg, {Bruce J.} and Yodha, {Arjun G.}",
note = "Funding Information: Funding for this study was provided through grants from the American College of Radiology Imaging Network, which receives funding from the National Cancer Institute (Nos. U01-CA079778 and U01-CA080098); the National Institutes of Health (Nos. P41-EB015893, R01-NS060653, R01-EB002109, R01-CA142989, P41-EB015890, U54-CA136400, T32-HL007915, R01-NS072338, and R01-NS082309-01A1); the Chao Family Comprehensive Cancer Center (No. P30-CA62203); the Thrasher Research Foundation; the Arnold and Mabel Beckman Foundation; and the June and Steve Wolfson Family Foundation. The diffuse optical spectroscopic imaging instrumentation used in this study was constructed in a university laboratory using federal grant support (NIH). The authors thank the entire ACRIN staff for their generous support in completing this study, including Donna Hartfeil, Sharon Mallet, and Dunstan Horng; UCI coordinators Montana Compton, Erin Sullivan, and Jennifer Ehren; UCI engineers Amanda Durkin and Brian Hill; UPenn coordinators Ellen Foster, Madeline Winters, and Sarah Grundy, Dr. Angela DeMichele and Dr. Julia Tchou, clinical coordinators at all sites, all clinicians who contributed to subject recruitment, and the patients who generously volunteered their time for this study.",
year = "2019",
month = jan,
day = "1",
doi = "10.1117/1.JBO.24.2.021202",
language = "English (US)",
volume = "24",
journal = "Journal of Biomedical Optics",
issn = "1083-3668",
publisher = "SPIE",
number = "2",
}