@article{77679001fe9044e0bf502cef811f8d4e,
title = "Tissue Pharmacologic and Virologic Determinants of Duodenal and Rectal Gastrointestinal-Associated Lymphoid Tissue Immune Reconstitution in HIV-Infected Patients Initiating Antiretroviral Therapy",
abstract = "Plasma, duodenal, and rectal tissue antiretroviral therapy (ART) drug concentrations, human immunodeficiency virus (HIV) RNA and HIV DNA copy numbers, and recovery of mucosal immunity were measured before and 9 months after initiation of 3 different ART regimens in 26 subjects. Plasma and tissue HIV RNA correlated at baseline and when 9-month declines were compared, suggesting that these compartments are tightly associated. Antiretroviral tissue:blood penetration ratios were above the 50% inhibitory concentration values in almost 100% of cases. There were no correlations between drug concentrations and HIV DNA/RNA. Importantly, no evidence was found for residual viral replication or deficient tissue drug penetration to account for delayed gastrointestinal-associated lymphoid tissue immune recovery.",
keywords = "ART tissue penetration, HIV persistence, antiretroviral concentration, gastrointestinal-associated lymphoid tissue, immune reconstitution",
author = "Asmuth, {David M.} and Thompson, {Corbin G.} and Chun, {Tae Wook} and Ma, {Zhong Min} and Surinder Mann and Talia Sainz and Sergio Serrano-Villar and Utay, {Netanya S.} and Garcia, {Juan Carlos} and Paolo Troia-Cancio and Pollard, {Richard B.} and Miller, {Christopher J.} and Alan Landay and Kashuba, {Angela D.}",
note = "Funding Information: Financial support. This work was made possible, in part, by the National Center for Research Resources to UCD (grant number UL1-RR024146); University of North Carolina Center for AIDS Research (grant number P30-AI027763); and the Spanish Ministry of Health and Innovation and the Spanish Network on AIDS Research (grant number RD06/006-SSV&TS). Potential conflicts of interest. All authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. Publisher Copyright: {\textcopyright} The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",
year = "2017",
month = nov,
day = "1",
doi = "10.1093/infdis/jix418",
language = "English (US)",
volume = "216",
pages = "813--818",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "7",
}