Tissue plasminogen activator: From molecular biology to myocardial infarction

K. R. Chien, R. Meidell, R. Gerard

Research output: Contribution to journalArticle

3 Scopus citations


The recent development of recombinant tissue plasminogen activator as a therapeutic agent during acute myocardial infarction is one of the most lucid examples of the potential impact of recombinant DNA technology in clinical medicine. This remarkable achievement would not have been possible without several key discoveries in molecular biology and clinical cardiology and exemplifies the synergistic relationship between basic and clinical research. This article chronicles this journey from molecular biology to myocardial infarction.

Original languageEnglish (US)
Pages (from-to)201-207
Number of pages7
JournalAmerican Journal of the Medical Sciences
Issue number3
Publication statusPublished - 1987


ASJC Scopus subject areas

  • Medicine(all)

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