Titanium-mediated oxidative arylation of homoallylic alcohols

Kathleen S. Lee, Joseph M. Ready

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

E-Substituted styrene derivatives are synthesized from terminal olefins and aryl Grignard reagents through TiIV-mediated oxidative coupling (see scheme). Substrates include homoallylic alcohols containing a range of functional groups and substituted aryl Grignard reagents. The reaction may proceed through aryltitanation followed by β-hydride elimination; reductive elimination of arene occurs from a TiIVH(aryl) intermediate.

Original languageEnglish (US)
Pages (from-to)2111-2114
Number of pages4
JournalAngewandte Chemie - International Edition
Volume50
Issue number9
DOIs
Publication statusPublished - Feb 25 2011

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Keywords

  • alcohols
  • Ci-C coupling
  • Grignard reagents
  • oxidative arylation
  • titanium reagents

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

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