Titrating autophagy in cardiac plasticity

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The heart is a highly plastic organ. In a recent study, we found that autophagy is a required element in load-induced cardiomyocyte growth; when autophagy is suppressed, the heart does not grow. Conversely, afterload stress triggers a transient increase in cardiomyocyte autophagic activity which settles to a new-higher-baseline once the heart has re-achieved steady-state size. Our work went on to decipher the role of histone deacetylases in this biology.

Original languageEnglish (US)
Pages (from-to)1078-1079
Number of pages2
JournalAutophagy
Volume7
Issue number9
DOIs
StatePublished - Sep 2011

Fingerprint

Autophagy
Cardiac Myocytes
Histone Deacetylases
Plastics
Growth

Keywords

  • Heart
  • Heart failure
  • Histone deacetylase
  • Hypertrophy
  • Remodeling

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Titrating autophagy in cardiac plasticity. / Cao, Dian J; Hill, Joseph A.

In: Autophagy, Vol. 7, No. 9, 09.2011, p. 1078-1079.

Research output: Contribution to journalArticle

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