TLR signaling pathways: Opportunities for activation and blockade in pursuit of therapy

K. Hoebe, Z. Jiang, P. Georgel, K. Tabeta, E. Janssen, X. Du, Bruce Beutler

Research output: Contribution to journalReview article

49 Scopus citations


The identification of the TLRs as key sensors of microbial infection has presented a series of new targets for drug development. The TLRs are linked to the most powerful inflammatory pathways in mammals. The question arises from the start: do we wish to stimulate TLR signaling in order to eradicate specific infections and/or neoplastic diseases? Or do we wish to block TLR signaling to treat inflammatory diseases? If we accept that it would be useful to modulate TLR signaling, the next step is to identify the correct molecular target(s) for the task. Perhaps it might even be possible to exercise selectivity, modulating some aspects of TLR signaling and not others. Classical and reverse genetic analyses offer insight into the possibilities that exist, and point to specific checkpoints within signaling pathways at which modulation might normally be imposed.

Original languageEnglish (US)
Pages (from-to)4123-4134
Number of pages12
JournalCurrent Pharmaceutical Design
Issue number32
StatePublished - Nov 2006


  • Microbial adjuvants
  • MyD88-dependent signal transduction
  • Sterile inflammation
  • TNF neutralization
  • Trif mutation

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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