TmDOTP5-: A substance for NMR temperature measurements in vivo

Chun S. Zuo, John L. Bowers, Kenneth R. Metz, Toshihisa Nosaka, A. Dean Sherry, Melvin E. Clouse

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

The chemical shifts of 31P and 1H in thulium 1,4,7,10- tetraazacyclododecane-1,4,7,10-tetrakis(methylene phosphonate) (TmDOTP5-) are approximately two orders of magnitude more sensitive to temperature than are water proton and 19F shifts. In the physiologically relevant pH range, the 31P and 1H chemical shifts of TmDOTP5- are linear functions of temperature between 25 and 47°C. The results indicate that using Tm-DOTP5- can provide measurements of temperature in vivo that are significantly more accurate than methods based on water and fluorocarbon chemical shifts.

Original languageEnglish (US)
Pages (from-to)955-959
Number of pages5
JournalMagnetic resonance in medicine
Volume36
Issue number6
DOIs
StatePublished - Dec 1996

Keywords

  • TmDOTP
  • magnetic resonance spectroscopy
  • temperature measurement

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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