TMPRSS2-ERG gene fusion prevalence and class are significantly different in prostate cancer of Caucasian, African-American and Japanese patients

Cristina Magi-Galluzzi, Toyonori Tsusuki, Paul Elson, Kelly Simmerman, Chris Lafargue, Raquel Esgueva, Eric Klein, Mark A. Rubin, Ming Zhou

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

Background Prostate cancer (PCa) exhibits significant differences in prevalence and mortality among different ethnic groups. The underlying genetics is not well understood. TMPRSS2-ERG fusion is a common recurrent chromosomal aberration in PCa and is however not studied among different ethnic groups. We examined the prevalence and class of TMPRSS2-ERG gene fusion in PCa from Caucasian, African-American, and Japanese patients. MATERIALS AND Methods A tissue microarray of PCa from 42 Caucasians, 64 African-Americans, and 44 Japanese patients who underwent radical prostatectomies (RP) was studied for TMPRSS2-ERG fusion using a multicolor interphase fluorescence in situ hybridization assay for ERG gene break-apart. Results TMPRSS2-ERG gene fusion was present in 50% (21/42) of Caucasians, 31.3% (20/64) of African-Americans, and 15.9% (7/44) of Japanese (P = 0.003). The gene fusion through translocation, deletion, or both occurred in 61.9% (13/21), 38.1% (8/21), and 0% (0/21) in Caucasians, 20% (4/20), 60% (12/20), and 20% (4/20) in African-Americans, and 71.4% (5/7), 28.6% (2/7), and 0% (0/7) in Japanese patients (P = 0.02). A multivariate analysis demonstrated that TMPRSS2-ERG gene fusion correlated with the ethnicity (P = 0.03), marginally correlated with the pathologic stage (P = 0.06), but not other clinicopathologic parameters, including age, preoperative PSA levels, and Gleason score. ConclusionS The prevalence and class of TMPRSS2-ERG are significantly different in PCa of Caucasian, African-American, and Japanese patients. Future studies of the molecular pathways implicated in TMPRSS2-ERG gene fusion may shed light on the disparity in prevalence and mortality of PCa among different ethnic groups and help design better prevention and treatment strategies. Prostate 77:489-497, 2011.

Original languageEnglish (US)
Pages (from-to)489-497
Number of pages9
JournalProstate
Volume71
Issue number5
DOIs
StatePublished - Apr 1 2011

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Gene Fusion
African Americans
Prostatic Neoplasms
Ethnic Groups
Mortality
Neoplasm Grading
Interphase
Prostatectomy
Fluorescence In Situ Hybridization
Chromosome Aberrations
Prostate
Multivariate Analysis
Genes

Keywords

  • ethnicity
  • prostate cancer
  • TMPRSS2-ERG gene fusion

ASJC Scopus subject areas

  • Urology
  • Oncology

Cite this

TMPRSS2-ERG gene fusion prevalence and class are significantly different in prostate cancer of Caucasian, African-American and Japanese patients. / Magi-Galluzzi, Cristina; Tsusuki, Toyonori; Elson, Paul; Simmerman, Kelly; Lafargue, Chris; Esgueva, Raquel; Klein, Eric; Rubin, Mark A.; Zhou, Ming.

In: Prostate, Vol. 71, No. 5, 01.04.2011, p. 489-497.

Research output: Contribution to journalArticle

Magi-Galluzzi, C, Tsusuki, T, Elson, P, Simmerman, K, Lafargue, C, Esgueva, R, Klein, E, Rubin, MA & Zhou, M 2011, 'TMPRSS2-ERG gene fusion prevalence and class are significantly different in prostate cancer of Caucasian, African-American and Japanese patients', Prostate, vol. 71, no. 5, pp. 489-497. https://doi.org/10.1002/pros.21265
Magi-Galluzzi, Cristina ; Tsusuki, Toyonori ; Elson, Paul ; Simmerman, Kelly ; Lafargue, Chris ; Esgueva, Raquel ; Klein, Eric ; Rubin, Mark A. ; Zhou, Ming. / TMPRSS2-ERG gene fusion prevalence and class are significantly different in prostate cancer of Caucasian, African-American and Japanese patients. In: Prostate. 2011 ; Vol. 71, No. 5. pp. 489-497.
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abstract = "Background Prostate cancer (PCa) exhibits significant differences in prevalence and mortality among different ethnic groups. The underlying genetics is not well understood. TMPRSS2-ERG fusion is a common recurrent chromosomal aberration in PCa and is however not studied among different ethnic groups. We examined the prevalence and class of TMPRSS2-ERG gene fusion in PCa from Caucasian, African-American, and Japanese patients. MATERIALS AND Methods A tissue microarray of PCa from 42 Caucasians, 64 African-Americans, and 44 Japanese patients who underwent radical prostatectomies (RP) was studied for TMPRSS2-ERG fusion using a multicolor interphase fluorescence in situ hybridization assay for ERG gene break-apart. Results TMPRSS2-ERG gene fusion was present in 50{\%} (21/42) of Caucasians, 31.3{\%} (20/64) of African-Americans, and 15.9{\%} (7/44) of Japanese (P = 0.003). The gene fusion through translocation, deletion, or both occurred in 61.9{\%} (13/21), 38.1{\%} (8/21), and 0{\%} (0/21) in Caucasians, 20{\%} (4/20), 60{\%} (12/20), and 20{\%} (4/20) in African-Americans, and 71.4{\%} (5/7), 28.6{\%} (2/7), and 0{\%} (0/7) in Japanese patients (P = 0.02). A multivariate analysis demonstrated that TMPRSS2-ERG gene fusion correlated with the ethnicity (P = 0.03), marginally correlated with the pathologic stage (P = 0.06), but not other clinicopathologic parameters, including age, preoperative PSA levels, and Gleason score. ConclusionS The prevalence and class of TMPRSS2-ERG are significantly different in PCa of Caucasian, African-American, and Japanese patients. Future studies of the molecular pathways implicated in TMPRSS2-ERG gene fusion may shed light on the disparity in prevalence and mortality of PCa among different ethnic groups and help design better prevention and treatment strategies. Prostate 77:489-497, 2011.",
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T1 - TMPRSS2-ERG gene fusion prevalence and class are significantly different in prostate cancer of Caucasian, African-American and Japanese patients

AU - Magi-Galluzzi, Cristina

AU - Tsusuki, Toyonori

AU - Elson, Paul

AU - Simmerman, Kelly

AU - Lafargue, Chris

AU - Esgueva, Raquel

AU - Klein, Eric

AU - Rubin, Mark A.

AU - Zhou, Ming

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N2 - Background Prostate cancer (PCa) exhibits significant differences in prevalence and mortality among different ethnic groups. The underlying genetics is not well understood. TMPRSS2-ERG fusion is a common recurrent chromosomal aberration in PCa and is however not studied among different ethnic groups. We examined the prevalence and class of TMPRSS2-ERG gene fusion in PCa from Caucasian, African-American, and Japanese patients. MATERIALS AND Methods A tissue microarray of PCa from 42 Caucasians, 64 African-Americans, and 44 Japanese patients who underwent radical prostatectomies (RP) was studied for TMPRSS2-ERG fusion using a multicolor interphase fluorescence in situ hybridization assay for ERG gene break-apart. Results TMPRSS2-ERG gene fusion was present in 50% (21/42) of Caucasians, 31.3% (20/64) of African-Americans, and 15.9% (7/44) of Japanese (P = 0.003). The gene fusion through translocation, deletion, or both occurred in 61.9% (13/21), 38.1% (8/21), and 0% (0/21) in Caucasians, 20% (4/20), 60% (12/20), and 20% (4/20) in African-Americans, and 71.4% (5/7), 28.6% (2/7), and 0% (0/7) in Japanese patients (P = 0.02). A multivariate analysis demonstrated that TMPRSS2-ERG gene fusion correlated with the ethnicity (P = 0.03), marginally correlated with the pathologic stage (P = 0.06), but not other clinicopathologic parameters, including age, preoperative PSA levels, and Gleason score. ConclusionS The prevalence and class of TMPRSS2-ERG are significantly different in PCa of Caucasian, African-American, and Japanese patients. Future studies of the molecular pathways implicated in TMPRSS2-ERG gene fusion may shed light on the disparity in prevalence and mortality of PCa among different ethnic groups and help design better prevention and treatment strategies. Prostate 77:489-497, 2011.

AB - Background Prostate cancer (PCa) exhibits significant differences in prevalence and mortality among different ethnic groups. The underlying genetics is not well understood. TMPRSS2-ERG fusion is a common recurrent chromosomal aberration in PCa and is however not studied among different ethnic groups. We examined the prevalence and class of TMPRSS2-ERG gene fusion in PCa from Caucasian, African-American, and Japanese patients. MATERIALS AND Methods A tissue microarray of PCa from 42 Caucasians, 64 African-Americans, and 44 Japanese patients who underwent radical prostatectomies (RP) was studied for TMPRSS2-ERG fusion using a multicolor interphase fluorescence in situ hybridization assay for ERG gene break-apart. Results TMPRSS2-ERG gene fusion was present in 50% (21/42) of Caucasians, 31.3% (20/64) of African-Americans, and 15.9% (7/44) of Japanese (P = 0.003). The gene fusion through translocation, deletion, or both occurred in 61.9% (13/21), 38.1% (8/21), and 0% (0/21) in Caucasians, 20% (4/20), 60% (12/20), and 20% (4/20) in African-Americans, and 71.4% (5/7), 28.6% (2/7), and 0% (0/7) in Japanese patients (P = 0.02). A multivariate analysis demonstrated that TMPRSS2-ERG gene fusion correlated with the ethnicity (P = 0.03), marginally correlated with the pathologic stage (P = 0.06), but not other clinicopathologic parameters, including age, preoperative PSA levels, and Gleason score. ConclusionS The prevalence and class of TMPRSS2-ERG are significantly different in PCa of Caucasian, African-American, and Japanese patients. Future studies of the molecular pathways implicated in TMPRSS2-ERG gene fusion may shed light on the disparity in prevalence and mortality of PCa among different ethnic groups and help design better prevention and treatment strategies. Prostate 77:489-497, 2011.

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