TMPRSS2-ERG gene fusion prevalence and class are significantly different in prostate cancer of Caucasian, African-American and Japanese patients

Cristina Magi-Galluzzi, Toyonori Tsusuki, Paul Elson, Kelly Simmerman, Chris Lafargue, Raquel Esgueva, Eric Klein, Mark A. Rubin, Ming Zhou

Research output: Contribution to journalArticle

170 Scopus citations

Abstract

Background Prostate cancer (PCa) exhibits significant differences in prevalence and mortality among different ethnic groups. The underlying genetics is not well understood. TMPRSS2-ERG fusion is a common recurrent chromosomal aberration in PCa and is however not studied among different ethnic groups. We examined the prevalence and class of TMPRSS2-ERG gene fusion in PCa from Caucasian, African-American, and Japanese patients. MATERIALS AND Methods A tissue microarray of PCa from 42 Caucasians, 64 African-Americans, and 44 Japanese patients who underwent radical prostatectomies (RP) was studied for TMPRSS2-ERG fusion using a multicolor interphase fluorescence in situ hybridization assay for ERG gene break-apart. Results TMPRSS2-ERG gene fusion was present in 50% (21/42) of Caucasians, 31.3% (20/64) of African-Americans, and 15.9% (7/44) of Japanese (P = 0.003). The gene fusion through translocation, deletion, or both occurred in 61.9% (13/21), 38.1% (8/21), and 0% (0/21) in Caucasians, 20% (4/20), 60% (12/20), and 20% (4/20) in African-Americans, and 71.4% (5/7), 28.6% (2/7), and 0% (0/7) in Japanese patients (P = 0.02). A multivariate analysis demonstrated that TMPRSS2-ERG gene fusion correlated with the ethnicity (P = 0.03), marginally correlated with the pathologic stage (P = 0.06), but not other clinicopathologic parameters, including age, preoperative PSA levels, and Gleason score. ConclusionS The prevalence and class of TMPRSS2-ERG are significantly different in PCa of Caucasian, African-American, and Japanese patients. Future studies of the molecular pathways implicated in TMPRSS2-ERG gene fusion may shed light on the disparity in prevalence and mortality of PCa among different ethnic groups and help design better prevention and treatment strategies. Prostate 77:489-497, 2011.

Original languageEnglish (US)
Pages (from-to)489-497
Number of pages9
JournalProstate
Volume71
Issue number5
DOIs
StatePublished - Apr 2011

Keywords

  • TMPRSS2-ERG gene fusion
  • ethnicity
  • prostate cancer

ASJC Scopus subject areas

  • Oncology
  • Urology

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    Magi-Galluzzi, C., Tsusuki, T., Elson, P., Simmerman, K., Lafargue, C., Esgueva, R., Klein, E., Rubin, M. A., & Zhou, M. (2011). TMPRSS2-ERG gene fusion prevalence and class are significantly different in prostate cancer of Caucasian, African-American and Japanese patients. Prostate, 71(5), 489-497. https://doi.org/10.1002/pros.21265