To automate or not to automate: This is the question

M. Cymborowski, M. Klimecka, M. Chruszcz, M. D. Zimmerman, I. A. Shumilin, D. Borek, K. Lazarski, A. Joachimiak, Z. Otwinowski, W. Anderson, W. Minor

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


New protocols and instrumentation significantly boost the outcome of structural biology, which has resulted in significant growth in the number of deposited Protein Data Bank structures. However, even an enormous increase of the productivity of a single step of the structure determination process may not significantly shorten the time between clone and deposition or publication. For example, in a medium size laboratory equipped with the LabDB and HKL-3000 systems, we show that automation of some (and integration of all) steps of the X-ray structure determination pathway is critical for laboratory productivity. Moreover, we show that the lag period after which the impact of a technology change is observed is longer than expected.

Original languageEnglish (US)
Pages (from-to)211-221
Number of pages11
JournalJournal of Structural and Functional Genomics
Issue number3
StatePublished - Sep 2010


  • Automation
  • Data collection
  • Databases
  • Ligand screening
  • Structural genomics
  • Structure determination

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Genetics


Dive into the research topics of 'To automate or not to automate: This is the question'. Together they form a unique fingerprint.

Cite this