Tolerability and efficacy of a novel formulation in the treatment of melasma

Ian L. Guevara, Kelly D. Werlinger, Amit G. Pandya

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Topical agents containing mixtures of hydroquinone and glycolic acid often cause irritation in patients with melasma. Objective: The authors assessed the safety and efficacy of a new cream containing hydroquinone (HQ), glycolic acid, and hyaluronic acid for epidermal melasma. Methods: Fifteen Latin American women with bilateral epidermal melasma underwent twice-daily full face application with the study cream for 12 weeks. A moisturizer was added if irritation developed. Results: Mexameter data revealed that 14 of 15 patients (93%) improved, and there was a significant decrease in MASI (melasma area and severity index) scores of 64% over the course of the study. Fifty-three percent of the patients required a moisturizer after eight weeks of treatment. The majority of adverse events were mild. Patient and physician global evaluation showed moderate, obvious or very marked improvement in all patients. Limitations: Open, uncontrolled trial in a small number of patients. Conclusion: A cream containing hydroquinone, glycolic acid and hyaluronic acid demonstrates improvement in patients with melasma.

Original languageEnglish (US)
Pages (from-to)215-218
Number of pages4
JournalJournal of Drugs in Dermatology
Volume9
Issue number3
StatePublished - Mar 2010

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Melanosis
glycolic acid
Hyaluronic Acid
Therapeutics
Physicians
Safety

ASJC Scopus subject areas

  • Dermatology

Cite this

Guevara, I. L., Werlinger, K. D., & Pandya, A. G. (2010). Tolerability and efficacy of a novel formulation in the treatment of melasma. Journal of Drugs in Dermatology, 9(3), 215-218.

Tolerability and efficacy of a novel formulation in the treatment of melasma. / Guevara, Ian L.; Werlinger, Kelly D.; Pandya, Amit G.

In: Journal of Drugs in Dermatology, Vol. 9, No. 3, 03.2010, p. 215-218.

Research output: Contribution to journalArticle

Guevara, IL, Werlinger, KD & Pandya, AG 2010, 'Tolerability and efficacy of a novel formulation in the treatment of melasma', Journal of Drugs in Dermatology, vol. 9, no. 3, pp. 215-218.
Guevara, Ian L. ; Werlinger, Kelly D. ; Pandya, Amit G. / Tolerability and efficacy of a novel formulation in the treatment of melasma. In: Journal of Drugs in Dermatology. 2010 ; Vol. 9, No. 3. pp. 215-218.
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