Tolerance to the anti-avoidance properties of cholecystokinin-octapeptide

Steven L. Cohen, Martha Knight, Carol A. Tamminga, Thomas N. Chase

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Previous investigations have suggested a neuroleptic-like action of cholecystokinin-octapeptide (CCK8) on conditioned-avoidance behavior. This study was initiated to test tolerance to this effect. Rats were trained to avoid electric shock in a shuttle box under a free-operant (Sidman) avoidance paradigm. Each shuttle response postponed a 0.2 sec, 1 mA shock for 20 sec. If the rat failed to respond, shock was delivered every 5 sec until a response occurred. After avoidance training, half of the rats received two daily injections of CCK8 (0.320 mg/kg, IP) and half received saline for 7 days. Rats were then tested on the Sidman avoidance 1 min after receiving CCK8 (0.640 mg/kg, IP) or saline. CCK8 depressed avoidance responding if rats received saline for 7 days prior to the test. Rats pretreated with CCK8 for 7 days were not significantly affected by CCK8 during the avoidance test. Thus, repeated injections of CCK8 result in tolerance to its anti-avoidance properties.

Original languageEnglish (US)
Pages (from-to)67-70
Number of pages4
JournalPeptides
Volume4
Issue number1
DOIs
StatePublished - 1983

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Sincalide
Rats
Shock
Avoidance Learning
Injections
Antipsychotic Agents

Keywords

  • Avoidance
  • Cholecystokinin-octapeptide
  • Peptide
  • Tolerance

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Tolerance to the anti-avoidance properties of cholecystokinin-octapeptide. / Cohen, Steven L.; Knight, Martha; Tamminga, Carol A.; Chase, Thomas N.

In: Peptides, Vol. 4, No. 1, 1983, p. 67-70.

Research output: Contribution to journalArticle

Cohen, Steven L. ; Knight, Martha ; Tamminga, Carol A. ; Chase, Thomas N. / Tolerance to the anti-avoidance properties of cholecystokinin-octapeptide. In: Peptides. 1983 ; Vol. 4, No. 1. pp. 67-70.
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