Toll-like receptor 2 (TLR2), transforming growth factor-β, hyaluronan (HA), and receptor for HA-mediated motility (RHAMM) are required for surfactant protein a-stimulated macrophage chemotaxis

Joseph P. Foley; David Lam; Hongmei Jiang; Jie Liao; Naeun Cheong; Theresa M. McDevitt; Aisha Zaman; Jo Rae Wright; Rashmin C. Savani

doi:10.1074/jbc.M112.360982

Toll-like receptor 2 (TLR2), transforming growth factor-β, hyaluronan (HA), and receptor for HA-mediated motility (RHAMM) are required for surfactant protein a-stimulated macrophage chemotaxis

Joseph P. Foley, David Lam, Hongmei Jiang, Jie Liao, Naeun Cheong, Theresa M. McDevitt, Aisha Zaman, Jo Rae Wright, Rashmin C. Savani

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Background: Surfactant protein A stimulates macrophage chemotaxis. Results: SPA interaction with TLR2 stimulates JNK- and ERK-dependent TGFβ production, which in turn stimulates RHAMM- and hyaluronan-dependent macrophage chemotaxis. Conclusion: SPA activates a novel and specific pathway to stimulate macrophage chemotaxis. Significance: Uncovering the mechanisms that regulate innate immunity in the lung is crucial for understanding the responses to infection and injury.

Original language	English (US)
Pages (from-to)	37406-37419
Number of pages	14
Journal	Journal of Biological Chemistry
Volume	287
Issue number	44
DOIs	https://doi.org/10.1074/jbc.M112.360982
State	Published - Oct 26 2012

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Foley, J. P., Lam, D., Jiang, H., Liao, J., Cheong, N., McDevitt, T. M., Zaman, A., Wright, J. R., & Savani, R. C. (2012). Toll-like receptor 2 (TLR2), transforming growth factor-β, hyaluronan (HA), and receptor for HA-mediated motility (RHAMM) are required for surfactant protein a-stimulated macrophage chemotaxis. Journal of Biological Chemistry, 287(44), 37406-37419. https://doi.org/10.1074/jbc.M112.360982

Toll-like receptor 2 (TLR2), transforming growth factor-β, hyaluronan (HA), and receptor for HA-mediated motility (RHAMM) are required for surfactant protein a-stimulated macrophage chemotaxis. / Foley, Joseph P.; Lam, David; Jiang, Hongmei et al.
In: Journal of Biological Chemistry, Vol. 287, No. 44, 26.10.2012, p. 37406-37419.

Research output: Contribution to journal › Article › peer-review

Foley, JP, Lam, D, Jiang, H, Liao, J, Cheong, N, McDevitt, TM, Zaman, A, Wright, JR & Savani, RC 2012, 'Toll-like receptor 2 (TLR2), transforming growth factor-β, hyaluronan (HA), and receptor for HA-mediated motility (RHAMM) are required for surfactant protein a-stimulated macrophage chemotaxis', Journal of Biological Chemistry, vol. 287, no. 44, pp. 37406-37419. https://doi.org/10.1074/jbc.M112.360982

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AU - Jiang, Hongmei

AU - Liao, Jie

AU - Cheong, Naeun

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AU - Zaman, Aisha

AU - Wright, Jo Rae

AU - Savani, Rashmin C.

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Toll-like receptor 2 (TLR2), transforming growth factor-β, hyaluronan (HA), and receptor for HA-mediated motility (RHAMM) are required for surfactant protein a-stimulated macrophage chemotaxis

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