Toll-like receptor 2 (TLR2), transforming growth factor-β, hyaluronan (HA), and receptor for HA-mediated motility (RHAMM) are required for surfactant protein a-stimulated macrophage chemotaxis

Joseph P. Foley, David Lam, Hongmei Jiang, Jie Liao, Naeun Cheong, Theresa M. McDevitt, Aisha Zaman, Jo Rae Wright, Rashmin C. Savani

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: Surfactant protein A stimulates macrophage chemotaxis. Results: SPA interaction with TLR2 stimulates JNK- and ERK-dependent TGFβ production, which in turn stimulates RHAMM- and hyaluronan-dependent macrophage chemotaxis. Conclusion: SPA activates a novel and specific pathway to stimulate macrophage chemotaxis. Significance: Uncovering the mechanisms that regulate innate immunity in the lung is crucial for understanding the responses to infection and injury.

Original languageEnglish (US)
Pages (from-to)37406-37419
Number of pages14
JournalJournal of Biological Chemistry
Volume287
Issue number44
DOIs
StatePublished - Oct 26 2012

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CD44 Antigens
Toll-Like Receptor 2
Growth Factor Receptors
Macrophages
Transforming Growth Factors
Chemotaxis
Hyaluronic Acid
Surface-Active Agents
Pulmonary Surfactant-Associated Protein A
Proteins
Innate Immunity
Lung
Wounds and Injuries
Infection

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Toll-like receptor 2 (TLR2), transforming growth factor-β, hyaluronan (HA), and receptor for HA-mediated motility (RHAMM) are required for surfactant protein a-stimulated macrophage chemotaxis. / Foley, Joseph P.; Lam, David; Jiang, Hongmei; Liao, Jie; Cheong, Naeun; McDevitt, Theresa M.; Zaman, Aisha; Wright, Jo Rae; Savani, Rashmin C.

In: Journal of Biological Chemistry, Vol. 287, No. 44, 26.10.2012, p. 37406-37419.

Research output: Contribution to journalArticle

Foley, Joseph P. ; Lam, David ; Jiang, Hongmei ; Liao, Jie ; Cheong, Naeun ; McDevitt, Theresa M. ; Zaman, Aisha ; Wright, Jo Rae ; Savani, Rashmin C. / Toll-like receptor 2 (TLR2), transforming growth factor-β, hyaluronan (HA), and receptor for HA-mediated motility (RHAMM) are required for surfactant protein a-stimulated macrophage chemotaxis. In: Journal of Biological Chemistry. 2012 ; Vol. 287, No. 44. pp. 37406-37419.
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