Toll-like receptor 2 (TLR2), transforming growth factor-β, hyaluronan (HA), and receptor for HA-mediated motility (RHAMM) are required for surfactant protein a-stimulated macrophage chemotaxis

Joseph P. Foley, David Lam, Hongmei Jiang, Jie Liao, Naeun Cheong, Theresa M. McDevitt, Aisha Zaman, Jo Rae Wright, Rashmin C. Savani

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Background: Surfactant protein A stimulates macrophage chemotaxis. Results: SPA interaction with TLR2 stimulates JNK- and ERK-dependent TGFβ production, which in turn stimulates RHAMM- and hyaluronan-dependent macrophage chemotaxis. Conclusion: SPA activates a novel and specific pathway to stimulate macrophage chemotaxis. Significance: Uncovering the mechanisms that regulate innate immunity in the lung is crucial for understanding the responses to infection and injury.

Original languageEnglish (US)
Pages (from-to)37406-37419
Number of pages14
JournalJournal of Biological Chemistry
Volume287
Issue number44
DOIs
StatePublished - Oct 26 2012

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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