Toll-like receptor recognition of Toxoplasma gondii

Felix Yarovinsky, Alan Sher

Research output: Contribution to journalComment/debatepeer-review

59 Scopus citations

Abstract

Toxoplasma gondii potently stimulates IFN-γ production by both the innate and adaptive immune system as part of its host adaptation. This response is known to be dependent on an Myeloid Differentiation factor 88 signaling pathway used by Toll-like receptors (TLRs), a family of proteins involved in the recognition of microbial molecular patterns. In the following review, we summarise the evidence for specific TLR function in host resistance to T. gondii focusing on the recent discovery in the parasite of a profilin-like ligand that potently stimulates TLR11 and regulates the production of IL-12, a cytokine necessary for the protective IFN-γ response. In addition, we discuss the hypothesis that TLR11 may have evolved as a general pattern recognition receptor for apicomplexan protozoa and that as highly conserved proteins associated with actin-based motility, profilins are logical ligand targets for this form of pathogen detection. Finally, we review the evidence for involvement of other TLR and TLR ligands in host resistance to T. gondii and discuss how such receptors might synergise with TLR11 in the innate response to the parasite.

Original languageEnglish (US)
Pages (from-to)255-259
Number of pages5
JournalInternational Journal for Parasitology
Volume36
Issue number3
DOIs
StatePublished - Mar 2006

Keywords

  • Apicomplexan protozoa
  • Dendritic cells
  • IL-12
  • Innate immunity
  • MyD88
  • TLR11
  • Toll-like receptors
  • Toxoplasma gondii

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Toll-like receptor recognition of Toxoplasma gondii'. Together they form a unique fingerprint.

Cite this