Toll-like receptor signaling and its relevance to intestinal inflammation

Elke Cario, Daniel K. Podolsky

Research output: Chapter in Book/Report/Conference proceedingConference contribution

25 Scopus citations

Abstract

This review discusses the current progress in the understanding of how commensal-mediated activation of toll-like receptors (TLRs) may be involved in the regulation of physiological and pathophysiological processes of the intestinal mucosa including tissue regeneration and inflammation. While regulation of TLRs and their downstream signaling mediators might be used to prevent and treat inflammatory bowel diseases, paradoxically, at this time, it remains uncertain whether this would be more effectively accomplished by enhancing or inhibiting these pathways.

Original languageEnglish (US)
Title of host publicationAnnals of the New York Academy of Sciences
Pages332-338
Number of pages7
Volume1072
DOIs
Publication statusPublished - 2006

Publication series

NameAnnals of the New York Academy of Sciences
Volume1072
ISSN (Print)00778923
ISSN (Electronic)17496632

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Keywords

  • Host defense
  • Inflammatory bowel diseases
  • Innate immunity
  • Intestinal epithelium
  • Resident microflora
  • Therapy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Cario, E., & Podolsky, D. K. (2006). Toll-like receptor signaling and its relevance to intestinal inflammation. In Annals of the New York Academy of Sciences (Vol. 1072, pp. 332-338). (Annals of the New York Academy of Sciences; Vol. 1072). https://doi.org/10.1196/annals.1326.006