Toll-like receptors and their role in host resistance to Toxoplasma gondii

Felix Yarovinsky

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Toxoplasma gondii and other apicomplexan parasites are widely distributed obligate intracellular protozoa. A critical host mediator produced in response to T. gondii infection is IL-12. This cytokine is synthesized by dendritic cells, macrophages and neutrophils and plays a pivotal role in the production of IFN-γ, which in turn activates anti-microbial effector cells. In the past several years, many of the receptors and signaling pathways that link pathogen detection to induction of IL-12 have been identified and characterized. Among these receptors the Toll-like receptor (TLR) family can recognize all classes of pathogens and induce different types of immune responses. In the following review, I summarize the evidence for specific TLR function in host resistance to T. gondii.

Original languageEnglish (US)
Pages (from-to)17-21
Number of pages5
JournalImmunology Letters
Volume119
Issue number1-2
DOIs
StatePublished - Aug 15 2008

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Toll-Like Receptors
Toxoplasma
Interleukin-12
Toxoplasmosis
Dendritic Cells
Parasites
Neutrophils
Macrophages
Cytokines

Keywords

  • Dendritic cells
  • IFN-γ
  • IL-12
  • TLR11
  • TLR2, MyD88
  • Toll-like receptors
  • Toxoplasma gondii

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Toll-like receptors and their role in host resistance to Toxoplasma gondii. / Yarovinsky, Felix.

In: Immunology Letters, Vol. 119, No. 1-2, 15.08.2008, p. 17-21.

Research output: Contribution to journalArticle

Yarovinsky, Felix. / Toll-like receptors and their role in host resistance to Toxoplasma gondii. In: Immunology Letters. 2008 ; Vol. 119, No. 1-2. pp. 17-21.
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