Toll-like receptors, signalingadapters and regulation of the pro-inflammatory response by PI3K

Ty Dale Troutman, J. Fernando Bazan, Chandrashekhar Pasare

Research output: Contribution to journalReview article

86 Scopus citations

Abstract

TLRs are a family of pattern recognition receptors that recognize conserved molecular structures/products from a wide variety of microbes.1,2Following recognition of ligands, TLRs recruit signaling adapters to initiate a pro-inflammatory signaling cascade culminating in the activation of several transcription factor families. Additionally, TLR signals lead to activation of PI3K, affecting many aspects of the cellular response, including cell survival, proliferation and regulation of the pro-inflammatory response.3-10 The recent discovery of BCAP as a TLR signaling adaptor, crucial for linking TLRs to PI3K activation, allows new questions of the importance of PI3K activation downstream of TLRs. Here, we summarize the current understanding of signaling pathways activated by TLRs and provide our perspective on TLR mediated activation of PI3K and its impact on regulating cellular processes.

Original languageEnglish (US)
Pages (from-to)3559-3567
Number of pages9
JournalCell Cycle
Volume11
Issue number19
DOIs
StatePublished - Oct 1 2012

Keywords

  • BCAP
  • Inflammation
  • Macrophage
  • PI3K
  • Toll-like receptor

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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