Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells

Chandrashekhar Pasare, Ruslan Medzhitov

Research output: Contribution to journalArticle

1739 Scopus citations

Abstract

Toll-like receptors (TLRS) control activation of adaptive immune responses by antigen-presenting cells (APCs). However, initiation of adaptive immune responses is also controlled by regulatory T cells (TR cells), which act to prevent activation of autoreactive T cells. Here we describe a second mechanism of immune induction by TLRs, which is independent of effects on costimulation. Microbial induction of the Toll pathway blocked the suppressive effect of CD4+CD25+ TR cells, allowing activation of pathogen-specific adaptive immune responses. This block of suppressor activity was dependent in part on interleukin-6, which was induced by TLRs upon recognition of microbial products.

Original languageEnglish (US)
Pages (from-to)1033-1036
Number of pages4
JournalScience
Volume299
Issue number5609
DOIs
StatePublished - Feb 14 2003

ASJC Scopus subject areas

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