Toll Receptor-Mediated Hippo Signaling Controls Innate Immunity in Drosophila

Bo Liu, Yonggang Zheng, Feng Yin, Jianzhong Yu, Neal Silverman, Duojia Pan

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Summary The Hippo signaling pathway functions through Yorkie to control tissue growth and homeostasis. How this pathway regulates non-developmental processes remains largely unexplored. Here, we report an essential role for Hippo signaling in innate immunity whereby Yorkie directly regulates the transcription of the Drosophila IκB homolog, Cactus, in Toll receptor-mediated antimicrobial response. Loss of Hippo pathway tumor suppressors or activation of Yorkie in fat bodies, the Drosophila immune organ, leads to elevated cactus mRNA levels, decreased expression of antimicrobial peptides, and vulnerability to infection by Gram-positive bacteria. Furthermore, Gram-positive bacteria acutely activate Hippo-Yorkie signaling in fat bodies via the Toll-Myd88-Pelle cascade through Pelle-mediated phosphorylation and degradation of the Cka subunit of the Hippo-inhibitory STRIPAK PP2A complex. Our studies elucidate a Toll-mediated Hippo signaling pathway in antimicrobial response, highlight the importance of regulating IκB/Cactus transcription in innate immunity, and identify Gram-positive bacteria as extracellular stimuli of Hippo signaling under physiological settings.

Original languageEnglish (US)
Pages (from-to)406-419
Number of pages14
JournalCell
Volume164
Issue number3
DOIs
StatePublished - Jan 28 2016

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Cactaceae
Gram-Positive Bacteria
Innate Immunity
Drosophila
Fat Body
Bacteria
Transcription
Fats
Homeostasis
Phosphorylation
Messenger RNA
Peptides
Tumors
Growth
Infection
Chemical activation
Neoplasms
Tissue
Degradation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Toll Receptor-Mediated Hippo Signaling Controls Innate Immunity in Drosophila. / Liu, Bo; Zheng, Yonggang; Yin, Feng; Yu, Jianzhong; Silverman, Neal; Pan, Duojia.

In: Cell, Vol. 164, No. 3, 28.01.2016, p. 406-419.

Research output: Contribution to journalArticle

Liu, B, Zheng, Y, Yin, F, Yu, J, Silverman, N & Pan, D 2016, 'Toll Receptor-Mediated Hippo Signaling Controls Innate Immunity in Drosophila', Cell, vol. 164, no. 3, pp. 406-419. https://doi.org/10.1016/j.cell.2015.12.029
Liu, Bo ; Zheng, Yonggang ; Yin, Feng ; Yu, Jianzhong ; Silverman, Neal ; Pan, Duojia. / Toll Receptor-Mediated Hippo Signaling Controls Innate Immunity in Drosophila. In: Cell. 2016 ; Vol. 164, No. 3. pp. 406-419.
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