Topical ciprofloxacin/dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of granulation tissue in children with acute otitis media with otorrhea through tympanostomy tubes

Peter S. Roland, Joseph E. Dohar, Brent J. Lanier, Robert Hekkenburg, Edward M. Lane, Peter J. Conroy, G. Michael Wall, Sheryl J. Dupre, Susan L. Potts

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Objective Comparison of topical ciprofloxacin/dexamethasone otic suspension (CIP/DEX) to ofloxacin otic solution (OFL) for treatment of granulation tissue in children with AOMT. Study design 599 children aged ≥6 months to 12 years with AOMT of up to 3 weeks' duration were enrolled. Patients received either CIP/DEX 4 drops twice daily for 7 days or OFL 5 drops twice daily for 10 days. Granulation tissue severity was graded at clinic visits on days 1, 3, 11, and 18. Results Granulation tissue was present in 90 of 599 AOMT patients (15.0%) at baseline. CIP/DEX treatment was superior to OFL for reduction of granulation tissue at the day 11 visit (81.3% compared with 56.1%, P = 0.0067) and the day 18 visit (91.7% compared with 73.2%, P = 0.0223). Both topical otic preparations are safe and well tolerated in pediatric patients. Conclusion CIP/DEX was superior to OFL in the treatment of granulation tissue in children with AOMT.

Original languageEnglish (US)
Pages (from-to)736-741
Number of pages6
JournalOtolaryngology - Head and Neck Surgery
Volume130
Issue number6
DOIs
StatePublished - Jun 2004

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Middle Ear Ventilation
Ofloxacin
Granulation Tissue
Otitis Media
Ciprofloxacin
Dexamethasone
Ear
Suspensions
Therapeutics
Ambulatory Care
Pediatrics

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Topical ciprofloxacin/dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of granulation tissue in children with acute otitis media with otorrhea through tympanostomy tubes. / Roland, Peter S.; Dohar, Joseph E.; Lanier, Brent J.; Hekkenburg, Robert; Lane, Edward M.; Conroy, Peter J.; Wall, G. Michael; Dupre, Sheryl J.; Potts, Susan L.

In: Otolaryngology - Head and Neck Surgery, Vol. 130, No. 6, 06.2004, p. 736-741.

Research output: Contribution to journalArticle

Roland, Peter S. ; Dohar, Joseph E. ; Lanier, Brent J. ; Hekkenburg, Robert ; Lane, Edward M. ; Conroy, Peter J. ; Wall, G. Michael ; Dupre, Sheryl J. ; Potts, Susan L. / Topical ciprofloxacin/dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of granulation tissue in children with acute otitis media with otorrhea through tympanostomy tubes. In: Otolaryngology - Head and Neck Surgery. 2004 ; Vol. 130, No. 6. pp. 736-741.
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abstract = "Objective Comparison of topical ciprofloxacin/dexamethasone otic suspension (CIP/DEX) to ofloxacin otic solution (OFL) for treatment of granulation tissue in children with AOMT. Study design 599 children aged ≥6 months to 12 years with AOMT of up to 3 weeks' duration were enrolled. Patients received either CIP/DEX 4 drops twice daily for 7 days or OFL 5 drops twice daily for 10 days. Granulation tissue severity was graded at clinic visits on days 1, 3, 11, and 18. Results Granulation tissue was present in 90 of 599 AOMT patients (15.0{\%}) at baseline. CIP/DEX treatment was superior to OFL for reduction of granulation tissue at the day 11 visit (81.3{\%} compared with 56.1{\%}, P = 0.0067) and the day 18 visit (91.7{\%} compared with 73.2{\%}, P = 0.0223). Both topical otic preparations are safe and well tolerated in pediatric patients. Conclusion CIP/DEX was superior to OFL in the treatment of granulation tissue in children with AOMT.",
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