Topical Clindamycin Therapy for Acne Vulgaris: A Cooperative Clinical Study

Larry E. Becker, Paul R. Bergstresser, David A. Whiting, William E. Clendenning, Richard L. Dobson, William P. Jordan, Edward Abell, Lloyd A. Lezotte, Peter E. Pochi, Jerome L. Shupack, Robert B. Sigafoes, Richard B. Stoughton, John J. Voorhees

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Eleven institutions participated in an eight-week controlled clinical study to evaluate treatment of acne vulgaris with topical clindamycin hydrochloride and clindamycin phosphate. Three hundred fifty-eight patients with comparable baseline pustule, papule, and nodule counts applied 1% clindamycin hydrochloride, 1% clindamycin phosphate, or a hydroalcoholic vehicle twice daily. Every two weeks, lesions were counted, and patients' evaluations of their acne conditions were scored. By week 8, pustule and papule counts in the groups who were receiving clindamycin were significantly lower than those in the group receiving placebo. Also, more patients who were receiving clindamycin thought their acne improved by week 8 (with significantly higher change-in-acne scores) than did the patients receiving placebo. Patients receiving clindamycin reported 12 episodes of diarrhea; only one episode was considered to be treatment related. These results substantiate the clinical impession that topical clindamycin is effective treatment for acne.

Original languageEnglish (US)
Pages (from-to)482-485
Number of pages4
JournalArchives of Dermatology
Volume117
Issue number8
DOIs
StatePublished - 1981

Fingerprint

Clindamycin
Acne Vulgaris
Therapeutics
Placebos
Clinical Studies
Diarrhea

ASJC Scopus subject areas

  • Dermatology

Cite this

Becker, L. E., Bergstresser, P. R., Whiting, D. A., Clendenning, W. E., Dobson, R. L., Jordan, W. P., ... Voorhees, J. J. (1981). Topical Clindamycin Therapy for Acne Vulgaris: A Cooperative Clinical Study. Archives of Dermatology, 117(8), 482-485. https://doi.org/10.1001/archderm.1981.01650080036024

Topical Clindamycin Therapy for Acne Vulgaris : A Cooperative Clinical Study. / Becker, Larry E.; Bergstresser, Paul R.; Whiting, David A.; Clendenning, William E.; Dobson, Richard L.; Jordan, William P.; Abell, Edward; Lezotte, Lloyd A.; Pochi, Peter E.; Shupack, Jerome L.; Sigafoes, Robert B.; Stoughton, Richard B.; Voorhees, John J.

In: Archives of Dermatology, Vol. 117, No. 8, 1981, p. 482-485.

Research output: Contribution to journalArticle

Becker, LE, Bergstresser, PR, Whiting, DA, Clendenning, WE, Dobson, RL, Jordan, WP, Abell, E, Lezotte, LA, Pochi, PE, Shupack, JL, Sigafoes, RB, Stoughton, RB & Voorhees, JJ 1981, 'Topical Clindamycin Therapy for Acne Vulgaris: A Cooperative Clinical Study', Archives of Dermatology, vol. 117, no. 8, pp. 482-485. https://doi.org/10.1001/archderm.1981.01650080036024
Becker LE, Bergstresser PR, Whiting DA, Clendenning WE, Dobson RL, Jordan WP et al. Topical Clindamycin Therapy for Acne Vulgaris: A Cooperative Clinical Study. Archives of Dermatology. 1981;117(8):482-485. https://doi.org/10.1001/archderm.1981.01650080036024
Becker, Larry E. ; Bergstresser, Paul R. ; Whiting, David A. ; Clendenning, William E. ; Dobson, Richard L. ; Jordan, William P. ; Abell, Edward ; Lezotte, Lloyd A. ; Pochi, Peter E. ; Shupack, Jerome L. ; Sigafoes, Robert B. ; Stoughton, Richard B. ; Voorhees, John J. / Topical Clindamycin Therapy for Acne Vulgaris : A Cooperative Clinical Study. In: Archives of Dermatology. 1981 ; Vol. 117, No. 8. pp. 482-485.
@article{63845b27dd964002a0a91d3169ba2c06,
title = "Topical Clindamycin Therapy for Acne Vulgaris: A Cooperative Clinical Study",
abstract = "Eleven institutions participated in an eight-week controlled clinical study to evaluate treatment of acne vulgaris with topical clindamycin hydrochloride and clindamycin phosphate. Three hundred fifty-eight patients with comparable baseline pustule, papule, and nodule counts applied 1{\%} clindamycin hydrochloride, 1{\%} clindamycin phosphate, or a hydroalcoholic vehicle twice daily. Every two weeks, lesions were counted, and patients' evaluations of their acne conditions were scored. By week 8, pustule and papule counts in the groups who were receiving clindamycin were significantly lower than those in the group receiving placebo. Also, more patients who were receiving clindamycin thought their acne improved by week 8 (with significantly higher change-in-acne scores) than did the patients receiving placebo. Patients receiving clindamycin reported 12 episodes of diarrhea; only one episode was considered to be treatment related. These results substantiate the clinical impession that topical clindamycin is effective treatment for acne.",
author = "Becker, {Larry E.} and Bergstresser, {Paul R.} and Whiting, {David A.} and Clendenning, {William E.} and Dobson, {Richard L.} and Jordan, {William P.} and Edward Abell and Lezotte, {Lloyd A.} and Pochi, {Peter E.} and Shupack, {Jerome L.} and Sigafoes, {Robert B.} and Stoughton, {Richard B.} and Voorhees, {John J.}",
year = "1981",
doi = "10.1001/archderm.1981.01650080036024",
language = "English (US)",
volume = "117",
pages = "482--485",
journal = "JAMA Dermatology",
issn = "2168-6068",
publisher = "American Medical Association",
number = "8",

}

TY - JOUR

T1 - Topical Clindamycin Therapy for Acne Vulgaris

T2 - A Cooperative Clinical Study

AU - Becker, Larry E.

AU - Bergstresser, Paul R.

AU - Whiting, David A.

AU - Clendenning, William E.

AU - Dobson, Richard L.

AU - Jordan, William P.

AU - Abell, Edward

AU - Lezotte, Lloyd A.

AU - Pochi, Peter E.

AU - Shupack, Jerome L.

AU - Sigafoes, Robert B.

AU - Stoughton, Richard B.

AU - Voorhees, John J.

PY - 1981

Y1 - 1981

N2 - Eleven institutions participated in an eight-week controlled clinical study to evaluate treatment of acne vulgaris with topical clindamycin hydrochloride and clindamycin phosphate. Three hundred fifty-eight patients with comparable baseline pustule, papule, and nodule counts applied 1% clindamycin hydrochloride, 1% clindamycin phosphate, or a hydroalcoholic vehicle twice daily. Every two weeks, lesions were counted, and patients' evaluations of their acne conditions were scored. By week 8, pustule and papule counts in the groups who were receiving clindamycin were significantly lower than those in the group receiving placebo. Also, more patients who were receiving clindamycin thought their acne improved by week 8 (with significantly higher change-in-acne scores) than did the patients receiving placebo. Patients receiving clindamycin reported 12 episodes of diarrhea; only one episode was considered to be treatment related. These results substantiate the clinical impession that topical clindamycin is effective treatment for acne.

AB - Eleven institutions participated in an eight-week controlled clinical study to evaluate treatment of acne vulgaris with topical clindamycin hydrochloride and clindamycin phosphate. Three hundred fifty-eight patients with comparable baseline pustule, papule, and nodule counts applied 1% clindamycin hydrochloride, 1% clindamycin phosphate, or a hydroalcoholic vehicle twice daily. Every two weeks, lesions were counted, and patients' evaluations of their acne conditions were scored. By week 8, pustule and papule counts in the groups who were receiving clindamycin were significantly lower than those in the group receiving placebo. Also, more patients who were receiving clindamycin thought their acne improved by week 8 (with significantly higher change-in-acne scores) than did the patients receiving placebo. Patients receiving clindamycin reported 12 episodes of diarrhea; only one episode was considered to be treatment related. These results substantiate the clinical impession that topical clindamycin is effective treatment for acne.

UR - http://www.scopus.com/inward/record.url?scp=84944968102&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944968102&partnerID=8YFLogxK

U2 - 10.1001/archderm.1981.01650080036024

DO - 10.1001/archderm.1981.01650080036024

M3 - Article

AN - SCOPUS:84944968102

VL - 117

SP - 482

EP - 485

JO - JAMA Dermatology

JF - JAMA Dermatology

SN - 2168-6068

IS - 8

ER -