Topical corn oil in the management of essential fatty acid deficiency

M. C. McCarthy, W. W. Turner, K. Whatley, G. L. Cottam

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Conflicting anecdotal reports about the efficacy of topical linoleate in managing essential fatty acid deficiency prompted this prospective study of 10 critically ill surgical patients receiving continuous total parenteral nutrition (TPN). Ten ml of corn oil (4800 mg of linoleate) were massaged into the skin daily commencing after 7.7 ± 3.8 (mean ± SD) days of fat-free intake. Plasma samples were obtained weekly. Total lipids were extracted and methylated, and fatty acids were quantitated by gas-liquid chromatography. The triene:tetraene ratio (20:3ω9/20:4ω6) increased progressively in patients despite corn oil therapy. In 89% of patients the ratio exceeded 0.2, which is diagnostic of essential fatty acid deficiency (EFAD). Topical application of corn oil does not prevent or treat EFAD in patients on TPN.

Original languageEnglish (US)
Pages (from-to)373-375
Number of pages3
JournalCritical Care Medicine
Volume11
Issue number5
StatePublished - 1983

Fingerprint

Essential Fatty Acids
Corn Oil
Total Parenteral Nutrition
Linoleic Acid
Critical Illness
Gas Chromatography
Fatty Acids
Fats
Prospective Studies
Lipids
Skin
Therapeutics

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

McCarthy, M. C., Turner, W. W., Whatley, K., & Cottam, G. L. (1983). Topical corn oil in the management of essential fatty acid deficiency. Critical Care Medicine, 11(5), 373-375.

Topical corn oil in the management of essential fatty acid deficiency. / McCarthy, M. C.; Turner, W. W.; Whatley, K.; Cottam, G. L.

In: Critical Care Medicine, Vol. 11, No. 5, 1983, p. 373-375.

Research output: Contribution to journalArticle

McCarthy, MC, Turner, WW, Whatley, K & Cottam, GL 1983, 'Topical corn oil in the management of essential fatty acid deficiency', Critical Care Medicine, vol. 11, no. 5, pp. 373-375.
McCarthy, M. C. ; Turner, W. W. ; Whatley, K. ; Cottam, G. L. / Topical corn oil in the management of essential fatty acid deficiency. In: Critical Care Medicine. 1983 ; Vol. 11, No. 5. pp. 373-375.
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