TY - JOUR
T1 - Topical Review
T2 - Use of Fetal Tissue in Foot and Ankle Surgery
AU - Hanselman, Andrew E.
AU - Lalli, Trapper A J
AU - Santrock, Robert D.
N1 - Funding Information:
RDS is a medical director and receives research funding from Amniox Medical (Marietta, GA).
Publisher Copyright:
© 2015, © 2015 The Author(s).
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Fetal tissues are well known for their therapeutic potential. They contain numerous growth factors, cytokines, and matrix components that promote regeneration of tissues while downregulating inflammation and scar formation. As a result, use of these treatments has expanded over the previous 20 years throughout various surgical specialties, including orthopaedics. With improved methods of sterilization, processing, and storage, surgeons need to be informed about the potential benefits of fetal tissue in foot and ankle surgery. The aim of this review is to provide a brief historical background, basic anatomy and physiology, and a current review of the literature in regard to chronic wounds, diabetic foot ulcerations, plantar fasciitis, tendon repair, adhesion prevention, nerve repair, and bone healing. Levels of Evidence: Level V: Expert Opinion
AB - Fetal tissues are well known for their therapeutic potential. They contain numerous growth factors, cytokines, and matrix components that promote regeneration of tissues while downregulating inflammation and scar formation. As a result, use of these treatments has expanded over the previous 20 years throughout various surgical specialties, including orthopaedics. With improved methods of sterilization, processing, and storage, surgeons need to be informed about the potential benefits of fetal tissue in foot and ankle surgery. The aim of this review is to provide a brief historical background, basic anatomy and physiology, and a current review of the literature in regard to chronic wounds, diabetic foot ulcerations, plantar fasciitis, tendon repair, adhesion prevention, nerve repair, and bone healing. Levels of Evidence: Level V: Expert Opinion
KW - amniotic membrane
KW - chorionic membrane
KW - fetal tissue
KW - placenta
KW - umbilical cord
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U2 - 10.1177/1938640015578513
DO - 10.1177/1938640015578513
M3 - Review article
C2 - 25813778
AN - SCOPUS:84938383591
VL - 8
SP - 297
EP - 304
JO - Foot and Ankle Specialist
JF - Foot and Ankle Specialist
SN - 1938-6400
IS - 4
ER -