Topographically divergent and convergent connectivity between premotor and primary motor cortex

Numa Dancause, Scott Barbay, Shawn B. Frost, Erik J. Plautz, Mihai Popescu, Philip M. Dixon, Ann M. Stowe, Kathleen M. Friel, Randolph J. Nudo

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

This study was undertaken to determine the topographic organization of connections between the forelimb representations of the ventral premotor cortex (PMv) and the primary motor cortex (M1). Intracortical microstimulation techniques were used in three experimentally naive squirrel monkeys to delineate the M1 and PMv forelimb representations in the hemisphere contralateral to the dominant hand. Small amounts of biotinylated dextran amine (BDA) were then injected in the PMv distal forelimb representation. Following tangential sectioning, the location of the injection core in PMv and BDA-labeled cell bodies and synaptic boutons in M1 were documented in relation to functional topography. Whereas the injection core was mainly located within the distal forelimb representation in PMv, BDA-labeled cell bodies and terminals were distributed over comparable proportions of proximal and distal forelimb representations in M1. These results suggest that neuronal populations within PMv send topographically divergent outputs to M1 and receive topographically convergent inputs from M1. Finally, we found that PMv projections to M1 were not evenly distributed but rather were directed consistently to three domains within the rostro-lateral portion of M1. To our knowledge, this is the first description of such a consistent clustering of PMv terminals within M1.

Original languageEnglish (US)
Pages (from-to)1057-1068
Number of pages12
JournalCerebral Cortex
Volume16
Issue number8
DOIs
StatePublished - Aug 2006

Fingerprint

Forelimb
Motor Cortex
Saimiri
Injections
Presynaptic Terminals
Cluster Analysis
Hand
Population
biotinylated dextran amine

Keywords

  • Hand
  • ICMS
  • M1
  • Neuroanatomy
  • PMv
  • Squirrel monkey

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dancause, N., Barbay, S., Frost, S. B., Plautz, E. J., Popescu, M., Dixon, P. M., ... Nudo, R. J. (2006). Topographically divergent and convergent connectivity between premotor and primary motor cortex. Cerebral Cortex, 16(8), 1057-1068. https://doi.org/10.1093/cercor/bhj049

Topographically divergent and convergent connectivity between premotor and primary motor cortex. / Dancause, Numa; Barbay, Scott; Frost, Shawn B.; Plautz, Erik J.; Popescu, Mihai; Dixon, Philip M.; Stowe, Ann M.; Friel, Kathleen M.; Nudo, Randolph J.

In: Cerebral Cortex, Vol. 16, No. 8, 08.2006, p. 1057-1068.

Research output: Contribution to journalArticle

Dancause, N, Barbay, S, Frost, SB, Plautz, EJ, Popescu, M, Dixon, PM, Stowe, AM, Friel, KM & Nudo, RJ 2006, 'Topographically divergent and convergent connectivity between premotor and primary motor cortex', Cerebral Cortex, vol. 16, no. 8, pp. 1057-1068. https://doi.org/10.1093/cercor/bhj049
Dancause N, Barbay S, Frost SB, Plautz EJ, Popescu M, Dixon PM et al. Topographically divergent and convergent connectivity between premotor and primary motor cortex. Cerebral Cortex. 2006 Aug;16(8):1057-1068. https://doi.org/10.1093/cercor/bhj049
Dancause, Numa ; Barbay, Scott ; Frost, Shawn B. ; Plautz, Erik J. ; Popescu, Mihai ; Dixon, Philip M. ; Stowe, Ann M. ; Friel, Kathleen M. ; Nudo, Randolph J. / Topographically divergent and convergent connectivity between premotor and primary motor cortex. In: Cerebral Cortex. 2006 ; Vol. 16, No. 8. pp. 1057-1068.
@article{e39f5446d9304ef389dc5370d9fc26f1,
title = "Topographically divergent and convergent connectivity between premotor and primary motor cortex",
abstract = "This study was undertaken to determine the topographic organization of connections between the forelimb representations of the ventral premotor cortex (PMv) and the primary motor cortex (M1). Intracortical microstimulation techniques were used in three experimentally naive squirrel monkeys to delineate the M1 and PMv forelimb representations in the hemisphere contralateral to the dominant hand. Small amounts of biotinylated dextran amine (BDA) were then injected in the PMv distal forelimb representation. Following tangential sectioning, the location of the injection core in PMv and BDA-labeled cell bodies and synaptic boutons in M1 were documented in relation to functional topography. Whereas the injection core was mainly located within the distal forelimb representation in PMv, BDA-labeled cell bodies and terminals were distributed over comparable proportions of proximal and distal forelimb representations in M1. These results suggest that neuronal populations within PMv send topographically divergent outputs to M1 and receive topographically convergent inputs from M1. Finally, we found that PMv projections to M1 were not evenly distributed but rather were directed consistently to three domains within the rostro-lateral portion of M1. To our knowledge, this is the first description of such a consistent clustering of PMv terminals within M1.",
keywords = "Hand, ICMS, M1, Neuroanatomy, PMv, Squirrel monkey",
author = "Numa Dancause and Scott Barbay and Frost, {Shawn B.} and Plautz, {Erik J.} and Mihai Popescu and Dixon, {Philip M.} and Stowe, {Ann M.} and Friel, {Kathleen M.} and Nudo, {Randolph J.}",
year = "2006",
month = "8",
doi = "10.1093/cercor/bhj049",
language = "English (US)",
volume = "16",
pages = "1057--1068",
journal = "Cerebral Cortex",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "8",

}

TY - JOUR

T1 - Topographically divergent and convergent connectivity between premotor and primary motor cortex

AU - Dancause, Numa

AU - Barbay, Scott

AU - Frost, Shawn B.

AU - Plautz, Erik J.

AU - Popescu, Mihai

AU - Dixon, Philip M.

AU - Stowe, Ann M.

AU - Friel, Kathleen M.

AU - Nudo, Randolph J.

PY - 2006/8

Y1 - 2006/8

N2 - This study was undertaken to determine the topographic organization of connections between the forelimb representations of the ventral premotor cortex (PMv) and the primary motor cortex (M1). Intracortical microstimulation techniques were used in three experimentally naive squirrel monkeys to delineate the M1 and PMv forelimb representations in the hemisphere contralateral to the dominant hand. Small amounts of biotinylated dextran amine (BDA) were then injected in the PMv distal forelimb representation. Following tangential sectioning, the location of the injection core in PMv and BDA-labeled cell bodies and synaptic boutons in M1 were documented in relation to functional topography. Whereas the injection core was mainly located within the distal forelimb representation in PMv, BDA-labeled cell bodies and terminals were distributed over comparable proportions of proximal and distal forelimb representations in M1. These results suggest that neuronal populations within PMv send topographically divergent outputs to M1 and receive topographically convergent inputs from M1. Finally, we found that PMv projections to M1 were not evenly distributed but rather were directed consistently to three domains within the rostro-lateral portion of M1. To our knowledge, this is the first description of such a consistent clustering of PMv terminals within M1.

AB - This study was undertaken to determine the topographic organization of connections between the forelimb representations of the ventral premotor cortex (PMv) and the primary motor cortex (M1). Intracortical microstimulation techniques were used in three experimentally naive squirrel monkeys to delineate the M1 and PMv forelimb representations in the hemisphere contralateral to the dominant hand. Small amounts of biotinylated dextran amine (BDA) were then injected in the PMv distal forelimb representation. Following tangential sectioning, the location of the injection core in PMv and BDA-labeled cell bodies and synaptic boutons in M1 were documented in relation to functional topography. Whereas the injection core was mainly located within the distal forelimb representation in PMv, BDA-labeled cell bodies and terminals were distributed over comparable proportions of proximal and distal forelimb representations in M1. These results suggest that neuronal populations within PMv send topographically divergent outputs to M1 and receive topographically convergent inputs from M1. Finally, we found that PMv projections to M1 were not evenly distributed but rather were directed consistently to three domains within the rostro-lateral portion of M1. To our knowledge, this is the first description of such a consistent clustering of PMv terminals within M1.

KW - Hand

KW - ICMS

KW - M1

KW - Neuroanatomy

KW - PMv

KW - Squirrel monkey

UR - http://www.scopus.com/inward/record.url?scp=33745786060&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745786060&partnerID=8YFLogxK

U2 - 10.1093/cercor/bhj049

DO - 10.1093/cercor/bhj049

M3 - Article

C2 - 16221929

AN - SCOPUS:33745786060

VL - 16

SP - 1057

EP - 1068

JO - Cerebral Cortex

JF - Cerebral Cortex

SN - 1047-3211

IS - 8

ER -