TY - JOUR
T1 - Total daily sleep duration and the risk of dementia
T2 - A prospective population-based study
AU - Benito-León, J.
AU - Bermejo-Pareja, F.
AU - Vega, S.
AU - Louis, E. D.
PY - 2009/9
Y1 - 2009/9
N2 - Background and purpose: We determined in a population-based study whether sleep duration was associated with an increased risk of incident dementia. Methods: In a population-based study in central Spain, participants were evaluated at baseline and 3 years later. Baseline demographic variables were recorded and participants indicated their daily sleep duration as the sum of night-time sleep and daytime napping. The average daily total sleep duration was grouped into five categories: ≤5 (short sleepers), 6, 7 (reference), 8, and ≥9 h (long sleepers). We identified all cases with incident dementia, diagnosed using DSM-IV criteria. Results: Three thousand two hundred eighty six participants with baseline information about sleep duration had a median duration of follow-up of 3.2 years. There were 140 incident cases of dementia. The relative risks (RR) for short sleepers and for long sleepers were 2.36 (95% CI = 1.07-5.21, P = 0.03) and 2.40 (95% CI = 1.20-4.81, P = 0.01), respectively. After adjustment for potential confounders, the RR was only marginally increased for short sleepers (1.87, 95% CI = 0.85-4.15, P = 0.12) but remained increased for long sleepers (2.18; 95% CI = 1.09-4.37, P = 0.03). Conclusions: Prolonged sleep duration (night-time sleep and daytime napping) may be associated with an increased risk of dementia.
AB - Background and purpose: We determined in a population-based study whether sleep duration was associated with an increased risk of incident dementia. Methods: In a population-based study in central Spain, participants were evaluated at baseline and 3 years later. Baseline demographic variables were recorded and participants indicated their daily sleep duration as the sum of night-time sleep and daytime napping. The average daily total sleep duration was grouped into five categories: ≤5 (short sleepers), 6, 7 (reference), 8, and ≥9 h (long sleepers). We identified all cases with incident dementia, diagnosed using DSM-IV criteria. Results: Three thousand two hundred eighty six participants with baseline information about sleep duration had a median duration of follow-up of 3.2 years. There were 140 incident cases of dementia. The relative risks (RR) for short sleepers and for long sleepers were 2.36 (95% CI = 1.07-5.21, P = 0.03) and 2.40 (95% CI = 1.20-4.81, P = 0.01), respectively. After adjustment for potential confounders, the RR was only marginally increased for short sleepers (1.87, 95% CI = 0.85-4.15, P = 0.12) but remained increased for long sleepers (2.18; 95% CI = 1.09-4.37, P = 0.03). Conclusions: Prolonged sleep duration (night-time sleep and daytime napping) may be associated with an increased risk of dementia.
KW - Elderly
KW - Epidemiology
KW - Incident dementia
KW - Sleep duration
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U2 - 10.1111/j.1468-1331.2009.02618.x
DO - 10.1111/j.1468-1331.2009.02618.x
M3 - Article
C2 - 19473367
AN - SCOPUS:68849112652
SN - 1351-5101
VL - 16
SP - 990
EP - 997
JO - European Journal of Neurology
JF - European Journal of Neurology
IS - 9
ER -