Total pancreatectomy for pancreatic adenocarcinoma: Evaluation of morbidity and long-term Survival

Sushanth Reddy, Christopher L. Wolfgang, John L. Cameron, Frederic Eckhauser, Michael A. Choti, Richard D. Schulick, Barish H. Edil, Timothy M. Pawlik

Research output: Contribution to journalArticle

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Abstract

Objective: To analyze relative perioperative and long-term outcomes of patients undergoing total pancreatectomy versus pancreaticoduodenectomy. Background: The role of total pancreatectomy has historically been limited due to concerns over increased morbidity, mortality, and perceived worse long-term outcome. Methods: Between 1970 and 2007, patients who underwent total pancreatectomy (n = 100) or pancreaticoduodenectomy (n = 1286) for adenocarcinoma were identified. Clinicopathologic, morbidity, and survival data were collected and analyzed. Results: Total pancreatectomy patients had larger median tumor size (4 cm vs. 3 cm; P < 0.001) but similar rates of vascular (50.0% vs. 54.7%) and perineural invasion (90.7% vs. 91.8%) (total pancreatectomy vs. pancreaticoduodenectomy, respectively, both P > 0.05). A similar proportion of total pancreatectomy (74.7%) and pancreaticoduodenectomy (78.3%) patients had N1 disease (P = 0.45). Total pan reatectomy patients had more lymph nodes harvested (27 vs. 16) and were less likely to have positive resection margins (22.2% vs. 43.7%) (total pancreatectomy vs. pancreaticoduodenectomy, respectively, both P < 0.0001). Total pancreatectomy was increasingly used over time (1970-1989, n = 10, 1990-1999, n = 37, 2000-2007, n = 53). Total pancreatectomy was associated with higher 30-day mortality compared with pancreaticoduodenectomy (8.0% vs. 1.5%, respectively; P = 0.0007). However, total pancreatectomy operative mortality decreased over time (1970-1989, 40%; 1990-1999, 8%; 2000-2007, 2%; P = 0.0002). While operative morbidity was higher following total pancreatectomy (69.0% vs. 38.6% for pancreaticoduodenectomy; P < 0.0001), most complications were minor (Clavien Grade 1-2) (59%). Total pancreatectomy and pancreaticoduodenectomy patients had comparable 5-year survival (18.9% vs. 18.5%, respectively, P = 0.32). Conclusions: Total pancreatectomy perioperative mortality dramatically decreased over time. Long-term survival following total pancreatectomy versus pancreaticoduodenectomy was equivalent. Total pancreatectomy should be performed when oncologically appropriate.

Original languageEnglish (US)
Pages (from-to)282-287
Number of pages6
JournalAnnals of Surgery
Volume250
Issue number2
DOIs
StatePublished - Aug 2009

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Pancreatectomy
Adenocarcinoma
Pancreaticoduodenectomy
Morbidity
Survival
Mortality

ASJC Scopus subject areas

  • Surgery

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Reddy, S., Wolfgang, C. L., Cameron, J. L., Eckhauser, F., Choti, M. A., Schulick, R. D., ... Pawlik, T. M. (2009). Total pancreatectomy for pancreatic adenocarcinoma: Evaluation of morbidity and long-term Survival. Annals of Surgery, 250(2), 282-287. https://doi.org/10.1097/SLA.0b013e3181ae9f93

Total pancreatectomy for pancreatic adenocarcinoma : Evaluation of morbidity and long-term Survival. / Reddy, Sushanth; Wolfgang, Christopher L.; Cameron, John L.; Eckhauser, Frederic; Choti, Michael A.; Schulick, Richard D.; Edil, Barish H.; Pawlik, Timothy M.

In: Annals of Surgery, Vol. 250, No. 2, 08.2009, p. 282-287.

Research output: Contribution to journalArticle

Reddy, S, Wolfgang, CL, Cameron, JL, Eckhauser, F, Choti, MA, Schulick, RD, Edil, BH & Pawlik, TM 2009, 'Total pancreatectomy for pancreatic adenocarcinoma: Evaluation of morbidity and long-term Survival', Annals of Surgery, vol. 250, no. 2, pp. 282-287. https://doi.org/10.1097/SLA.0b013e3181ae9f93
Reddy, Sushanth ; Wolfgang, Christopher L. ; Cameron, John L. ; Eckhauser, Frederic ; Choti, Michael A. ; Schulick, Richard D. ; Edil, Barish H. ; Pawlik, Timothy M. / Total pancreatectomy for pancreatic adenocarcinoma : Evaluation of morbidity and long-term Survival. In: Annals of Surgery. 2009 ; Vol. 250, No. 2. pp. 282-287.
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abstract = "Objective: To analyze relative perioperative and long-term outcomes of patients undergoing total pancreatectomy versus pancreaticoduodenectomy. Background: The role of total pancreatectomy has historically been limited due to concerns over increased morbidity, mortality, and perceived worse long-term outcome. Methods: Between 1970 and 2007, patients who underwent total pancreatectomy (n = 100) or pancreaticoduodenectomy (n = 1286) for adenocarcinoma were identified. Clinicopathologic, morbidity, and survival data were collected and analyzed. Results: Total pancreatectomy patients had larger median tumor size (4 cm vs. 3 cm; P < 0.001) but similar rates of vascular (50.0{\%} vs. 54.7{\%}) and perineural invasion (90.7{\%} vs. 91.8{\%}) (total pancreatectomy vs. pancreaticoduodenectomy, respectively, both P > 0.05). A similar proportion of total pancreatectomy (74.7{\%}) and pancreaticoduodenectomy (78.3{\%}) patients had N1 disease (P = 0.45). Total pan reatectomy patients had more lymph nodes harvested (27 vs. 16) and were less likely to have positive resection margins (22.2{\%} vs. 43.7{\%}) (total pancreatectomy vs. pancreaticoduodenectomy, respectively, both P < 0.0001). Total pancreatectomy was increasingly used over time (1970-1989, n = 10, 1990-1999, n = 37, 2000-2007, n = 53). Total pancreatectomy was associated with higher 30-day mortality compared with pancreaticoduodenectomy (8.0{\%} vs. 1.5{\%}, respectively; P = 0.0007). However, total pancreatectomy operative mortality decreased over time (1970-1989, 40{\%}; 1990-1999, 8{\%}; 2000-2007, 2{\%}; P = 0.0002). While operative morbidity was higher following total pancreatectomy (69.0{\%} vs. 38.6{\%} for pancreaticoduodenectomy; P < 0.0001), most complications were minor (Clavien Grade 1-2) (59{\%}). Total pancreatectomy and pancreaticoduodenectomy patients had comparable 5-year survival (18.9{\%} vs. 18.5{\%}, respectively, P = 0.32). Conclusions: Total pancreatectomy perioperative mortality dramatically decreased over time. Long-term survival following total pancreatectomy versus pancreaticoduodenectomy was equivalent. Total pancreatectomy should be performed when oncologically appropriate.",
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AU - Choti, Michael A.

AU - Schulick, Richard D.

AU - Edil, Barish H.

AU - Pawlik, Timothy M.

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N2 - Objective: To analyze relative perioperative and long-term outcomes of patients undergoing total pancreatectomy versus pancreaticoduodenectomy. Background: The role of total pancreatectomy has historically been limited due to concerns over increased morbidity, mortality, and perceived worse long-term outcome. Methods: Between 1970 and 2007, patients who underwent total pancreatectomy (n = 100) or pancreaticoduodenectomy (n = 1286) for adenocarcinoma were identified. Clinicopathologic, morbidity, and survival data were collected and analyzed. Results: Total pancreatectomy patients had larger median tumor size (4 cm vs. 3 cm; P < 0.001) but similar rates of vascular (50.0% vs. 54.7%) and perineural invasion (90.7% vs. 91.8%) (total pancreatectomy vs. pancreaticoduodenectomy, respectively, both P > 0.05). A similar proportion of total pancreatectomy (74.7%) and pancreaticoduodenectomy (78.3%) patients had N1 disease (P = 0.45). Total pan reatectomy patients had more lymph nodes harvested (27 vs. 16) and were less likely to have positive resection margins (22.2% vs. 43.7%) (total pancreatectomy vs. pancreaticoduodenectomy, respectively, both P < 0.0001). Total pancreatectomy was increasingly used over time (1970-1989, n = 10, 1990-1999, n = 37, 2000-2007, n = 53). Total pancreatectomy was associated with higher 30-day mortality compared with pancreaticoduodenectomy (8.0% vs. 1.5%, respectively; P = 0.0007). However, total pancreatectomy operative mortality decreased over time (1970-1989, 40%; 1990-1999, 8%; 2000-2007, 2%; P = 0.0002). While operative morbidity was higher following total pancreatectomy (69.0% vs. 38.6% for pancreaticoduodenectomy; P < 0.0001), most complications were minor (Clavien Grade 1-2) (59%). Total pancreatectomy and pancreaticoduodenectomy patients had comparable 5-year survival (18.9% vs. 18.5%, respectively, P = 0.32). Conclusions: Total pancreatectomy perioperative mortality dramatically decreased over time. Long-term survival following total pancreatectomy versus pancreaticoduodenectomy was equivalent. Total pancreatectomy should be performed when oncologically appropriate.

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