Total synthesis of (+)-dihydrocompactin

Yuh Lin Yang, Sukumar Manna, J R Falck

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The potent hypocholesterolemic agent (+)-dihydrocompactin was synthesized by union of the masked lactone 5, ultimately derived from a carbohydrate precursor with the requisite absolute configuration, and hydronaphthalene 10, which was obtained from maleic anhydride Diels-Alder adduct 7 by intramolecular sulfone acylation. Extension of this sequence to the hydronaphthalene portion of dihydromevinolin is also described.

Original languageEnglish (US)
Pages (from-to)3811-3814
Number of pages4
JournalJournal of the American Chemical Society
Volume106
Issue number13
StatePublished - 1984

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Maleic Anhydrides
Acylation
Sulfones
Maleic anhydride
Lactones
Carbohydrates
dihydromevinolin
dihydrocompactin

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Total synthesis of (+)-dihydrocompactin. / Yang, Yuh Lin; Manna, Sukumar; Falck, J R.

In: Journal of the American Chemical Society, Vol. 106, No. 13, 1984, p. 3811-3814.

Research output: Contribution to journalArticle

Yang, YL, Manna, S & Falck, JR 1984, 'Total synthesis of (+)-dihydrocompactin', Journal of the American Chemical Society, vol. 106, no. 13, pp. 3811-3814.
Yang, Yuh Lin ; Manna, Sukumar ; Falck, J R. / Total synthesis of (+)-dihydrocompactin. In: Journal of the American Chemical Society. 1984 ; Vol. 106, No. 13. pp. 3811-3814.
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