Total Synthesis of (+)-Dihydrocompactin

Yuh Lin Yang, Sukumar Manna, J R Falck

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

The potent hypocholesterolemic agent (+)-dihydrocompactin was synthesized by union of the masked lactone 5, ultimately derived from a carbohydrate precursor with the requisite absolute configuration, and hydronaphthalene 10, which was obtained from maleic anhydride Diels-Alder adduct 7 by intramolecular sulfone acylation. Extension of this sequence to the hydronaphthalene portion of dihydromevinolin is also described.

Original languageEnglish (US)
Pages (from-to)3811-3814
Number of pages4
JournalJournal of the American Chemical Society
Volume106
Issue number13
DOIs
StatePublished - Jan 1984

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ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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