Total synthesis of the dictyodendrins as an arena to highlight emerging synthetic technologies

Wenhan Zhang, Joseph M. Ready

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Covering: 1993-2017 This review discusses the isolation, biological activity, and syntheses of the dictyodendrin class of natural products, covering the years 1993-2017. The dictyodendrins are a family of alkaloids isolated from marine sponges, Dictyodendrilla verongiformis and Ianthella sp., which possess a highly substituted pyrrolo[2,3-c]carbazole core at the phenol or quinone oxidation states. Dictyodendrins exhibit a wide range of biological activities, such as telomerase inhibition, BACE1 enzyme inhibition, and cytotoxicity against several cancer cell lines. The unique structure and interesting biological activities of dictyodendrins provided a platform for the application of novel synthetic methods including C-H insertion, C-H arylation, and electrocyclization cascades.

Original languageEnglish (US)
Pages (from-to)1010-1034
Number of pages25
JournalNatural Product Reports
Volume34
Issue number8
DOIs
StatePublished - Aug 1 2017

Fingerprint

Telomerase
Porifera
Phenol
Bioactivity
Biological Products
Alkaloids
Technology
Cell Line
Enzymes
Enzyme inhibition
Neoplasms
Cytotoxicity
Cells
Oxidation
benzoquinone
carbazole

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Total synthesis of the dictyodendrins as an arena to highlight emerging synthetic technologies. / Zhang, Wenhan; Ready, Joseph M.

In: Natural Product Reports, Vol. 34, No. 8, 01.08.2017, p. 1010-1034.

Research output: Contribution to journalReview article

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