Total synthesis of the dictyodendrins as an arena to highlight emerging synthetic technologies

Wenhan Zhang, Joseph M. Ready

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Covering: 1993-2017 This review discusses the isolation, biological activity, and syntheses of the dictyodendrin class of natural products, covering the years 1993-2017. The dictyodendrins are a family of alkaloids isolated from marine sponges, Dictyodendrilla verongiformis and Ianthella sp., which possess a highly substituted pyrrolo[2,3-c]carbazole core at the phenol or quinone oxidation states. Dictyodendrins exhibit a wide range of biological activities, such as telomerase inhibition, BACE1 enzyme inhibition, and cytotoxicity against several cancer cell lines. The unique structure and interesting biological activities of dictyodendrins provided a platform for the application of novel synthetic methods including C-H insertion, C-H arylation, and electrocyclization cascades.

Original languageEnglish (US)
Pages (from-to)1010-1034
Number of pages25
JournalNatural Product Reports
Volume34
Issue number8
DOIs
StatePublished - Aug 2017

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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