Toward an objective classification of cells in the immune system

I. Lefkovits, L. Kuhn, O. Valiron, A. Merle, J. Kettman

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The relative abundance of individual proteins shared among clones of lymphocytes provides a meaningful basis for cellular classification. Twelve clones of T cells (obtained by limiting dilution) were analyzed by two-dimensional gel electrophoresis for polypeptide content and then evaluated by the computational technique known as principal component analysis. As a result, relatedness of the clones was established and expressed in terms of taxonomic distances. The data show that a comprehensive and objective classification of the cells involved in the immune system can be approached.

Original languageEnglish (US)
Pages (from-to)3565-3569
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume85
Issue number10
DOIs
StatePublished - Jan 1 1988

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