Toward an objective classification of cells in the immune system

I. Lefkovits, L. Kuhn, O. Valiron, A. Merle, J. Kettman

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The relative abundance of individual proteins shared among clones of lymphocytes provides a meaningful basis for cellular classification. Twelve clones of T cells (obtained by limiting dilution) were analyzed by two-dimensional gel electrophoresis for polypeptide content and then evaluated by the computational technique known as principal component analysis. As a result, relatedness of the clones was established and expressed in terms of taxonomic distances. The data show that a comprehensive and objective classification of the cells involved in the immune system can be approached.

Original languageEnglish (US)
Pages (from-to)3565-3569
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume85
Issue number10
StatePublished - 1988

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Immune System
Clone Cells
Electrophoresis, Gel, Two-Dimensional
Principal Component Analysis
Lymphocytes
T-Lymphocytes
Peptides
Proteins

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

Toward an objective classification of cells in the immune system. / Lefkovits, I.; Kuhn, L.; Valiron, O.; Merle, A.; Kettman, J.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, No. 10, 1988, p. 3565-3569.

Research output: Contribution to journalArticle

Lefkovits, I, Kuhn, L, Valiron, O, Merle, A & Kettman, J 1988, 'Toward an objective classification of cells in the immune system', Proceedings of the National Academy of Sciences of the United States of America, vol. 85, no. 10, pp. 3565-3569.
Lefkovits, I. ; Kuhn, L. ; Valiron, O. ; Merle, A. ; Kettman, J. / Toward an objective classification of cells in the immune system. In: Proceedings of the National Academy of Sciences of the United States of America. 1988 ; Vol. 85, No. 10. pp. 3565-3569.
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