Towards a better understanding of postprandial hyperglycemic episodes in people with diabetes: impact on daily functioning

Simon Heller, Luigi F Meneghini, Annie Nikolajsen, Nana Kragh, Hannah B. Lewis, Todd Saretsky, Charlotte E. Kosmas, Andrew Lloyd

Research output: Contribution to journalArticle

Abstract

Objective: Acute postprandial hyperglycemia (aPPHG) is often symptomatic and can be associated with behavioral changes such as impaired working memory and attention. However, there is little evidence of the impact of aPPHG on the daily lives of patients. The aim of this study was to explore the frequency and severity of aPPHG episodes and their impact on daily functioning in people with insulin-treated diabetes. Methods: Adults (n = 1200) with insulin-treated diabetes mellitus type 1 (T1DM) or 2 (T2DM), most of whom experienced aPPHG, were recruited to complete an online cross-sectional survey in the USA and UK. The survey captured self-reported severity and frequency of aPPHG episodes and included a newly developed questionnaire (aPPHG-Q) assessing the impact of aPPHG episodes on patients’ daily lives. Data was analyzed separately according to diabetes type and country. Regression analyses were used to assess the relationship between severity or frequency and scores on the aPPHG-Q. Results: Between 70% and 86% of USA, and 87% and 88% of UK participants reported experiencing aPPHG episodes. Increasing frequency and severity of aPPHG episodes were associated with worse scores on the aPPHG-Q in patients with both T1DM and T2DM in both countries (p <.014) on all subscale scores (excluding the worry and concerns scores for T1DM in the UK), although the magnitude of the association was smaller for aPPHG frequency. Conclusions: Increased severity and frequency of aPPHG episodes in patients with insulin-treated diabetes is associated with greater burden and experience of symptoms, and can negatively impact daily functioning.

Original languageEnglish (US)
Pages (from-to)525-533
Number of pages9
JournalCurrent Medical Research and Opinion
Volume35
Issue number3
DOIs
StatePublished - Mar 4 2019

Keywords

  • Diabetes mellitus
  • diabetes mellitus
  • hyperglycemia
  • insulin
  • postprandial
  • type 1
  • type 2

ASJC Scopus subject areas

  • Medicine(all)

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