Towards a Synthesis of Epothilone A: Rapid Assembly of the C1-C6 and C7-C12 Fragments

Jef De Brabander, Stephane Rosset, Gérald Bernardinelli

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Abstract

A very short 4-step synthesis of the C1-C6 and C7-C12 fragments 3 and 4 of epothilone A (1a), starting from bornane-10,2-sultam 5, was achieved in 77% and 56% overall yield respectively.

Original languageEnglish (US)
Pages (from-to)824-826
Number of pages3
JournalSynlett
Volume1997
Issue number7
Publication statusPublished - 1997

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ASJC Scopus subject areas

  • Organic Chemistry

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