Towards detection of brain injury using multimodal non-invasive neuromonitoring in adults undergoing extracorporeal membrane oxygenation

Irfaan A. Dar, Imad R. Khan, Ross K. Maddox, Olga Selioutski, Kelly L. Donohue, Mark A. Marinescu, Sunil M. Prasad, Nadim H. Quazi, Jack S. Donlon, Emily A. Loose, Gabriel A. Ramirez, Jingxuan Ren, Joseph B. Majeski, Kenneth Abramson, Turgut Durduran, David R. Busch, Regine Choe

Research output: Contribution to journalArticlepeer-review

Abstract

Extracorporeal membrane oxygenation (ECMO) is a form of cardiopulmonary bypass that provides life-saving support to critically ill patients whose illness is progressing despite maximal conventional support. Use in adults is expanding, however neurological injuries are common. Currently, the existing brain imaging tools are a snapshot in time and require high-risk patient transport. Here we assess the feasibility of measuring diffuse correlation spectroscopy, transcranial Doppler ultrasound, electroencephalography, and auditory brainstem responses at the bedside, and developing a cerebral autoregulation metric. We report preliminary results from two patients, demonstrating feasibility and laying the foundation for future studies monitoring neurological health during ECMO.

Original languageEnglish (US)
Pages (from-to)6551-6569
Number of pages19
JournalBiomedical Optics Express
Volume11
Issue number11
DOIs
StatePublished - Nov 1 2020

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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