Towards the asymmetric synthesis of bryostatin 1

Jef De Brabander, Maurits Vandewalle

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The construction of the fragments C1-C9 3 and C17-C27 4a of the bryostatins in a enantioselective and highly diastereoselective fashion is described. The usefulness of the "chiron" approach is illustrated with the synthesis of these fragments from respectively D-pantolactone (6) and D-isobutyl lactate (14) as chiral templates.

Original languageEnglish (US)
Pages (from-to)715-718
Number of pages4
JournalPure and Applied Chemistry
Volume68
Issue number3
StatePublished - Mar 1996

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Bryostatins
pantolactone
isobutyl lactate
chiron
bryostatin 1

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Towards the asymmetric synthesis of bryostatin 1. / De Brabander, Jef; Vandewalle, Maurits.

In: Pure and Applied Chemistry, Vol. 68, No. 3, 03.1996, p. 715-718.

Research output: Contribution to journalArticle

De Brabander, Jef ; Vandewalle, Maurits. / Towards the asymmetric synthesis of bryostatin 1. In: Pure and Applied Chemistry. 1996 ; Vol. 68, No. 3. pp. 715-718.
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