Towards the asymmetric synthesis of bryostatin 1

Jef De Brabander, Maurits Vandewalle

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The construction of the fragments C1-C9 3 and C17-C27 4a of the bryostatins in a enantioselective and highly diastereoselective fashion is described. The usefulness of the "chiron" approach is illustrated with the synthesis of these fragments from respectively D-pantolactone (6) and D-isobutyl lactate (14) as chiral templates.

Original languageEnglish (US)
Pages (from-to)715-718
Number of pages4
JournalPure and Applied Chemistry
Volume68
Issue number3
DOIs
StatePublished - Mar 1996

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Fingerprint Dive into the research topics of 'Towards the asymmetric synthesis of bryostatin 1'. Together they form a unique fingerprint.

  • Cite this