Towards the rational design of MRI contrast agents

A practical approach to the synthesis of gadolinium complexes that exhibit optimal water exchange

Mark Woods, Mauro Botta, Stefano Avedano, Jing Wang, A. Dean Sherry

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

The gadolinium(III) complex of S-SSSS-NO2BnDOTMA exhibits water exchange kinetics that are optimal for use in high relaxivity or targeted contrast agents. However, the synthesis of this ligand is hampered by the steric encumbrance imparted upon the cyclen ring by the nitrobenzyl substituent. A relatively simple modification has been used to enable the synthesis of larger quantities of a bifunctional ligand that retains similar fast water exchange properties. The gadolinium complex of S-SSSS-NO2BnDO3MA-1A is shown to retain the rapid water exchange kinetics characteristic of a twisted square antiprismatic (TSAP) coordination geometry (τM = 6 ±0.4 ns).

Original languageEnglish (US)
Pages (from-to)3829-3837
Number of pages9
JournalDalton Transactions
Issue number24
DOIs
StatePublished - Dec 21 2005

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Gadolinium
Magnetic resonance imaging
Contrast Media
Ion exchange
Water
Ligands
Kinetics
Geometry

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Towards the rational design of MRI contrast agents : A practical approach to the synthesis of gadolinium complexes that exhibit optimal water exchange. / Woods, Mark; Botta, Mauro; Avedano, Stefano; Wang, Jing; Sherry, A. Dean.

In: Dalton Transactions, No. 24, 21.12.2005, p. 3829-3837.

Research output: Contribution to journalArticle

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