Toxicity of cecal filtrates from guinea pigs with penicillin-associated colitis

J. E. Rehg, B. A. Yarbrough, S. P. Pakes

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

Lethal enterocolitis was induced in guinea pigs by intramuscular injection of penicillin. The presence of a filterable toxic substance in the cecal contents of penicillin-treated guinea pigs was demonstrated. The toxin was heat-labile and produced enterosorption activity in rabbit intestinal loops and morphologic changes in Y-1 adrenal cell cultures. The cecal filtrates were lethal for mice when injected intraperitoneally and lethal for guinea pigs when injected intraperitoneally or intracecally. Cecal filtrates from saline-treated guinea pigs were not lethal to experimental animals. Filtrates prepared from broth cultures of cecal contents from penicillin or saline-treated guinea pigs also showed the presence of a lethal toxic substance. This study demonstrated that bacteremia is minimal, nonspecific and probably a terminal event in penicillin-associated deaths in guinea pigs.

Original languageEnglish (US)
Title of host publicationLaboratory Animal Science
Pages524-531
Number of pages8
Volume30
Edition3
StatePublished - 1980

Fingerprint

Colitis
Penicillins
Guinea Pigs
Poisons
Enterosorption
Enterocolitis
Intramuscular Injections
Bacteremia
Cell Culture Techniques
Hot Temperature
Rabbits

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rehg, J. E., Yarbrough, B. A., & Pakes, S. P. (1980). Toxicity of cecal filtrates from guinea pigs with penicillin-associated colitis. In Laboratory Animal Science (3 ed., Vol. 30, pp. 524-531)

Toxicity of cecal filtrates from guinea pigs with penicillin-associated colitis. / Rehg, J. E.; Yarbrough, B. A.; Pakes, S. P.

Laboratory Animal Science. Vol. 30 3. ed. 1980. p. 524-531.

Research output: Chapter in Book/Report/Conference proceedingChapter

Rehg, JE, Yarbrough, BA & Pakes, SP 1980, Toxicity of cecal filtrates from guinea pigs with penicillin-associated colitis. in Laboratory Animal Science. 3 edn, vol. 30, pp. 524-531.
Rehg JE, Yarbrough BA, Pakes SP. Toxicity of cecal filtrates from guinea pigs with penicillin-associated colitis. In Laboratory Animal Science. 3 ed. Vol. 30. 1980. p. 524-531
Rehg, J. E. ; Yarbrough, B. A. ; Pakes, S. P. / Toxicity of cecal filtrates from guinea pigs with penicillin-associated colitis. Laboratory Animal Science. Vol. 30 3. ed. 1980. pp. 524-531
@inbook{87c68c8a818b430fbb01fc732115000e,
title = "Toxicity of cecal filtrates from guinea pigs with penicillin-associated colitis",
abstract = "Lethal enterocolitis was induced in guinea pigs by intramuscular injection of penicillin. The presence of a filterable toxic substance in the cecal contents of penicillin-treated guinea pigs was demonstrated. The toxin was heat-labile and produced enterosorption activity in rabbit intestinal loops and morphologic changes in Y-1 adrenal cell cultures. The cecal filtrates were lethal for mice when injected intraperitoneally and lethal for guinea pigs when injected intraperitoneally or intracecally. Cecal filtrates from saline-treated guinea pigs were not lethal to experimental animals. Filtrates prepared from broth cultures of cecal contents from penicillin or saline-treated guinea pigs also showed the presence of a lethal toxic substance. This study demonstrated that bacteremia is minimal, nonspecific and probably a terminal event in penicillin-associated deaths in guinea pigs.",
author = "Rehg, {J. E.} and Yarbrough, {B. A.} and Pakes, {S. P.}",
year = "1980",
language = "English (US)",
volume = "30",
pages = "524--531",
booktitle = "Laboratory Animal Science",
edition = "3",

}

TY - CHAP

T1 - Toxicity of cecal filtrates from guinea pigs with penicillin-associated colitis

AU - Rehg, J. E.

AU - Yarbrough, B. A.

AU - Pakes, S. P.

PY - 1980

Y1 - 1980

N2 - Lethal enterocolitis was induced in guinea pigs by intramuscular injection of penicillin. The presence of a filterable toxic substance in the cecal contents of penicillin-treated guinea pigs was demonstrated. The toxin was heat-labile and produced enterosorption activity in rabbit intestinal loops and morphologic changes in Y-1 adrenal cell cultures. The cecal filtrates were lethal for mice when injected intraperitoneally and lethal for guinea pigs when injected intraperitoneally or intracecally. Cecal filtrates from saline-treated guinea pigs were not lethal to experimental animals. Filtrates prepared from broth cultures of cecal contents from penicillin or saline-treated guinea pigs also showed the presence of a lethal toxic substance. This study demonstrated that bacteremia is minimal, nonspecific and probably a terminal event in penicillin-associated deaths in guinea pigs.

AB - Lethal enterocolitis was induced in guinea pigs by intramuscular injection of penicillin. The presence of a filterable toxic substance in the cecal contents of penicillin-treated guinea pigs was demonstrated. The toxin was heat-labile and produced enterosorption activity in rabbit intestinal loops and morphologic changes in Y-1 adrenal cell cultures. The cecal filtrates were lethal for mice when injected intraperitoneally and lethal for guinea pigs when injected intraperitoneally or intracecally. Cecal filtrates from saline-treated guinea pigs were not lethal to experimental animals. Filtrates prepared from broth cultures of cecal contents from penicillin or saline-treated guinea pigs also showed the presence of a lethal toxic substance. This study demonstrated that bacteremia is minimal, nonspecific and probably a terminal event in penicillin-associated deaths in guinea pigs.

UR - http://www.scopus.com/inward/record.url?scp=0019309884&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019309884&partnerID=8YFLogxK

M3 - Chapter

C2 - 7431852

AN - SCOPUS:0019309884

VL - 30

SP - 524

EP - 531

BT - Laboratory Animal Science

ER -