Tracking adipogenesis during white adipose tissue development, expansion and regeneration

Qiong A. Wang, Caroline Tao, Rana K Gupta, Philipp E Scherer

Research output: Contribution to journalArticle

564 Scopus citations

Abstract

White adipose tissue displays high plasticity. We developed a system for the inducible, permanent labeling of mature adipocytes that we called the AdipoChaser mouse. We monitored adipogenesis during development, high-fat diet (HFD) feeding and cold exposure. During cold-induced 'browning' of subcutaneous fat, most 'beige' adipocytes stem from de novo-differentiated adipocytes. During HFD feeding, epididymal fat initiates adipogenesis after 4 weeks, whereas subcutaneous fat undergoes hypertrophy for a period of up to 12 weeks. Gonadal fat develops postnatally, whereas subcutaneous fat develops between embryonic days 14 and 18. Our results highlight the extensive differences in adipogenic potential in various fat depots.

Original languageEnglish (US)
Pages (from-to)1338-1344
Number of pages7
JournalNature medicine
Volume19
Issue number10
DOIs
StatePublished - Oct 1 2013

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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