Tracking spindle checkpoint signals from kinetochores to APC/C

Luying Jia, Soonjoung Kim, Hongtao Yu

Research output: Contribution to journalReview article

90 Scopus citations

Abstract

Accurate chromosome segregation during mitosis is critical for maintaining genomic stability. The kinetochore - a large protein assembly on centromeric chromatin - functions as the docking site for spindle microtubules and a signaling hub for the spindle checkpoint. At metaphase, spindle microtubules from opposing spindle poles capture each pair of sister kinetochores, exert pulling forces, and create tension across sister kinetochores. The spindle checkpoint detects improper kinetochore-microtubule attachments and translates these defects into biochemical activities that inhibit the anaphase-promoting complex or cyclosome (APC/C) throughout the cell to delay anaphase onset. A deficient spindle checkpoint leads to premature sister-chromatid separation and aneuploidy. Here, we review recent progress on the generation, propagation, transmission, and silencing of the spindle checkpoint signals from kinetochores to APC/C.

Original languageEnglish (US)
Pages (from-to)302-311
Number of pages10
JournalTrends in Biochemical Sciences
Volume38
Issue number6
DOIs
StatePublished - Jun 1 2013

Keywords

  • Chromosome segregation
  • Conformational change
  • Genomic stability
  • Mitosis
  • Regulated protein-protein interaction
  • Ubiquitination

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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