Traction microscopy to identify force modulation in subresolution adhesions

Sangyoon J. Han, Youbean Oak, Alex Groisman, Gaudenz Danuser

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

We present a reconstruction algorithm that resolves cellular tractions in diffraction-limited nascent adhesions (NAs). The enabling method is the introduction of sparsity regularization to the solution of the inverse problem, which suppresses noise without underestimating traction magnitude. We show that NAs transmit a distinguishable amount of traction and that NA maturation depends on traction growth rate. A software package implementing this numerical approach is provided.

Original languageEnglish (US)
Pages (from-to)653-656
Number of pages4
JournalNature Methods
Volume12
Issue number7
DOIs
StatePublished - Jun 30 2015

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Biochemistry
  • Cell Biology

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