TRAF3: a new component of the TLR-signaling apparatus

Kasper Hoebe, Bruce Beutler

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Toll-like receptors (TLRs) are key sensors of microbially derived molecules that, upon activation, provide a pathogen-specific inflammatory response, leading to an efficient eradication of microbial pathogens. An important question has been how TLRs can provide signaling diversity when challenged with genotypic and functionally distinct pathogens. Recently, two studies have shown that tumor-necrosis factor receptor-associated factor 3 (TRAF3) is an essential component of the TLR-signaling pathway, being a crucial regulator in the induction of TLR-specific inflammatory responses.

Original languageEnglish (US)
Pages (from-to)187-189
Number of pages3
JournalTrends in Molecular Medicine
Volume12
Issue number5
DOIs
StatePublished - May 2006

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Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Toll-Like Receptors

ASJC Scopus subject areas

  • Medicine(all)

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TRAF3 : a new component of the TLR-signaling apparatus. / Hoebe, Kasper; Beutler, Bruce.

In: Trends in Molecular Medicine, Vol. 12, No. 5, 05.2006, p. 187-189.

Research output: Contribution to journalArticle

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